Signaling pathways governing the behaviors of leukemia stem cells

Leukemia is a malignancy in the blood that develops from the lymphatic system and bone marrow. Although various treatment options have been used for different types of leukemia, understanding the molecular pathways involved in the development and progression of leukemia is necessary. Recent studies...

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Autores principales: Azizidoost, Shirin, Nasrolahi, Ava, Sheykhi-Sabzehpoush, Mohadeseh, Anbiyaiee, Amir, Khoshnam, Seyed Esmaeil, Farzaneh, Maryam, Uddin, Shahab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491880/
https://www.ncbi.nlm.nih.gov/pubmed/37692500
http://dx.doi.org/10.1016/j.gendis.2023.01.008
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author Azizidoost, Shirin
Nasrolahi, Ava
Sheykhi-Sabzehpoush, Mohadeseh
Anbiyaiee, Amir
Khoshnam, Seyed Esmaeil
Farzaneh, Maryam
Uddin, Shahab
author_facet Azizidoost, Shirin
Nasrolahi, Ava
Sheykhi-Sabzehpoush, Mohadeseh
Anbiyaiee, Amir
Khoshnam, Seyed Esmaeil
Farzaneh, Maryam
Uddin, Shahab
author_sort Azizidoost, Shirin
collection PubMed
description Leukemia is a malignancy in the blood that develops from the lymphatic system and bone marrow. Although various treatment options have been used for different types of leukemia, understanding the molecular pathways involved in the development and progression of leukemia is necessary. Recent studies showed that leukemia stem cells (LSCs) play essential roles in the pathogenesis of leukemia by targeting several signaling pathways, including Notch, Wnt, Hedgehog, and STAT3. LSCs are highly proliferative cells that stimulate tumor initiation, migration, EMT, and drug resistance. This review summarizes cellular pathways that stimulate and prevent LSCs' self-renewal, metastasis, and tumorigenesis.
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spelling pubmed-104918802023-09-10 Signaling pathways governing the behaviors of leukemia stem cells Azizidoost, Shirin Nasrolahi, Ava Sheykhi-Sabzehpoush, Mohadeseh Anbiyaiee, Amir Khoshnam, Seyed Esmaeil Farzaneh, Maryam Uddin, Shahab Genes Dis Review Article Leukemia is a malignancy in the blood that develops from the lymphatic system and bone marrow. Although various treatment options have been used for different types of leukemia, understanding the molecular pathways involved in the development and progression of leukemia is necessary. Recent studies showed that leukemia stem cells (LSCs) play essential roles in the pathogenesis of leukemia by targeting several signaling pathways, including Notch, Wnt, Hedgehog, and STAT3. LSCs are highly proliferative cells that stimulate tumor initiation, migration, EMT, and drug resistance. This review summarizes cellular pathways that stimulate and prevent LSCs' self-renewal, metastasis, and tumorigenesis. Chongqing Medical University 2023-03-23 /pmc/articles/PMC10491880/ /pubmed/37692500 http://dx.doi.org/10.1016/j.gendis.2023.01.008 Text en © 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review Article
Azizidoost, Shirin
Nasrolahi, Ava
Sheykhi-Sabzehpoush, Mohadeseh
Anbiyaiee, Amir
Khoshnam, Seyed Esmaeil
Farzaneh, Maryam
Uddin, Shahab
Signaling pathways governing the behaviors of leukemia stem cells
title Signaling pathways governing the behaviors of leukemia stem cells
title_full Signaling pathways governing the behaviors of leukemia stem cells
title_fullStr Signaling pathways governing the behaviors of leukemia stem cells
title_full_unstemmed Signaling pathways governing the behaviors of leukemia stem cells
title_short Signaling pathways governing the behaviors of leukemia stem cells
title_sort signaling pathways governing the behaviors of leukemia stem cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491880/
https://www.ncbi.nlm.nih.gov/pubmed/37692500
http://dx.doi.org/10.1016/j.gendis.2023.01.008
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