E674Q (Shanghai APP mutant), a novel amyloid precursor protein mutation, in familial late-onset Alzheimer's disease

Identified as the pathogenic genes of Alzheimer's disease (AD), APP, PSEN1, and PSEN2 mainly lead to early-onset AD, whose course is more aggressive, and atypical symptoms are more common than sporadic AD. Here, a novel missense mutation, APP E674Q (also named “Shanghai APP”), was detected in a...

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Detalles Bibliográficos
Autores principales: Zhang, Yongfang, Xie, Xinyi, Chen, Boyu, Pan, Lina, Li, Jianping, Wang, Wanbing, Wang, Jintao, Tang, Ran, Huang, Qiang, Chen, Xiaofen, Ren, Rujing, Zhang, Zhentao, Fu, Wei, Wang, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2023
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491941/
https://www.ncbi.nlm.nih.gov/pubmed/37692508
http://dx.doi.org/10.1016/j.gendis.2023.02.051

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