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The Association Between Ventricular Fibrillation and Serum Catecholamine Levels

Background and objective Epinephrine (Ep) is the first choice as a vasoconstrictor in cardiopulmonary resuscitation (CPR) for patients with cardiopulmonary arrest (CPA); however, the Ep concentration in the serum of CPA patients is still unclear. The aim of this study was to evaluate the association...

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Autores principales: Oshima, Kiyohiro, Sawada, Yusuke, Isshiki, Yuta, Ichikawa, Yumi, Fukushima, Kazunori, Aramaki, Yuto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491946/
https://www.ncbi.nlm.nih.gov/pubmed/37692701
http://dx.doi.org/10.7759/cureus.43252
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author Oshima, Kiyohiro
Sawada, Yusuke
Isshiki, Yuta
Ichikawa, Yumi
Fukushima, Kazunori
Aramaki, Yuto
author_facet Oshima, Kiyohiro
Sawada, Yusuke
Isshiki, Yuta
Ichikawa, Yumi
Fukushima, Kazunori
Aramaki, Yuto
author_sort Oshima, Kiyohiro
collection PubMed
description Background and objective Epinephrine (Ep) is the first choice as a vasoconstrictor in cardiopulmonary resuscitation (CPR) for patients with cardiopulmonary arrest (CPA); however, the Ep concentration in the serum of CPA patients is still unclear. The aim of this study was to evaluate the association between serum Ep levels and achieving the return of spontaneous circulation (ROSC) in out-of-hospital cardiac arrest (OHCA) patients with ventricular fibrillation (VF). Methods This was a prospective, observational clinical study involving OHCA patients with VF transferred to our hospital from July 2014 to July 2017. The measurement of serum catecholamines [Ep, norepinephrine (Nep), and dopamine (DOA)] and vasopressin [antidiuretic hormone (ADH)] levels was performed with blood samples obtained immediately upon patients' arrival at our hospital. Patients were classified into two groups: the ROSC(+) group and ROSC(−) group; the serum concentrations of catecholamines and ADH were compared between these two groups. Results The serum Ep and Nep levels were lower in the ROSC(+) group than those in the ROSC(−) group and the difference was statistically significant. On the other hand, no significant differences were found in serum DOA and ADH levels between the two groups. Conclusions The results of this study suggest that an increment in serum Ep levels does not promote achieving ROSC in OHCA patients with VF.
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spelling pubmed-104919462023-09-10 The Association Between Ventricular Fibrillation and Serum Catecholamine Levels Oshima, Kiyohiro Sawada, Yusuke Isshiki, Yuta Ichikawa, Yumi Fukushima, Kazunori Aramaki, Yuto Cureus Cardiology Background and objective Epinephrine (Ep) is the first choice as a vasoconstrictor in cardiopulmonary resuscitation (CPR) for patients with cardiopulmonary arrest (CPA); however, the Ep concentration in the serum of CPA patients is still unclear. The aim of this study was to evaluate the association between serum Ep levels and achieving the return of spontaneous circulation (ROSC) in out-of-hospital cardiac arrest (OHCA) patients with ventricular fibrillation (VF). Methods This was a prospective, observational clinical study involving OHCA patients with VF transferred to our hospital from July 2014 to July 2017. The measurement of serum catecholamines [Ep, norepinephrine (Nep), and dopamine (DOA)] and vasopressin [antidiuretic hormone (ADH)] levels was performed with blood samples obtained immediately upon patients' arrival at our hospital. Patients were classified into two groups: the ROSC(+) group and ROSC(−) group; the serum concentrations of catecholamines and ADH were compared between these two groups. Results The serum Ep and Nep levels were lower in the ROSC(+) group than those in the ROSC(−) group and the difference was statistically significant. On the other hand, no significant differences were found in serum DOA and ADH levels between the two groups. Conclusions The results of this study suggest that an increment in serum Ep levels does not promote achieving ROSC in OHCA patients with VF. Cureus 2023-08-10 /pmc/articles/PMC10491946/ /pubmed/37692701 http://dx.doi.org/10.7759/cureus.43252 Text en Copyright © 2023, Oshima et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Oshima, Kiyohiro
Sawada, Yusuke
Isshiki, Yuta
Ichikawa, Yumi
Fukushima, Kazunori
Aramaki, Yuto
The Association Between Ventricular Fibrillation and Serum Catecholamine Levels
title The Association Between Ventricular Fibrillation and Serum Catecholamine Levels
title_full The Association Between Ventricular Fibrillation and Serum Catecholamine Levels
title_fullStr The Association Between Ventricular Fibrillation and Serum Catecholamine Levels
title_full_unstemmed The Association Between Ventricular Fibrillation and Serum Catecholamine Levels
title_short The Association Between Ventricular Fibrillation and Serum Catecholamine Levels
title_sort association between ventricular fibrillation and serum catecholamine levels
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491946/
https://www.ncbi.nlm.nih.gov/pubmed/37692701
http://dx.doi.org/10.7759/cureus.43252
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