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The Association Between Ventricular Fibrillation and Serum Catecholamine Levels
Background and objective Epinephrine (Ep) is the first choice as a vasoconstrictor in cardiopulmonary resuscitation (CPR) for patients with cardiopulmonary arrest (CPA); however, the Ep concentration in the serum of CPA patients is still unclear. The aim of this study was to evaluate the association...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491946/ https://www.ncbi.nlm.nih.gov/pubmed/37692701 http://dx.doi.org/10.7759/cureus.43252 |
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author | Oshima, Kiyohiro Sawada, Yusuke Isshiki, Yuta Ichikawa, Yumi Fukushima, Kazunori Aramaki, Yuto |
author_facet | Oshima, Kiyohiro Sawada, Yusuke Isshiki, Yuta Ichikawa, Yumi Fukushima, Kazunori Aramaki, Yuto |
author_sort | Oshima, Kiyohiro |
collection | PubMed |
description | Background and objective Epinephrine (Ep) is the first choice as a vasoconstrictor in cardiopulmonary resuscitation (CPR) for patients with cardiopulmonary arrest (CPA); however, the Ep concentration in the serum of CPA patients is still unclear. The aim of this study was to evaluate the association between serum Ep levels and achieving the return of spontaneous circulation (ROSC) in out-of-hospital cardiac arrest (OHCA) patients with ventricular fibrillation (VF). Methods This was a prospective, observational clinical study involving OHCA patients with VF transferred to our hospital from July 2014 to July 2017. The measurement of serum catecholamines [Ep, norepinephrine (Nep), and dopamine (DOA)] and vasopressin [antidiuretic hormone (ADH)] levels was performed with blood samples obtained immediately upon patients' arrival at our hospital. Patients were classified into two groups: the ROSC(+) group and ROSC(−) group; the serum concentrations of catecholamines and ADH were compared between these two groups. Results The serum Ep and Nep levels were lower in the ROSC(+) group than those in the ROSC(−) group and the difference was statistically significant. On the other hand, no significant differences were found in serum DOA and ADH levels between the two groups. Conclusions The results of this study suggest that an increment in serum Ep levels does not promote achieving ROSC in OHCA patients with VF. |
format | Online Article Text |
id | pubmed-10491946 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-104919462023-09-10 The Association Between Ventricular Fibrillation and Serum Catecholamine Levels Oshima, Kiyohiro Sawada, Yusuke Isshiki, Yuta Ichikawa, Yumi Fukushima, Kazunori Aramaki, Yuto Cureus Cardiology Background and objective Epinephrine (Ep) is the first choice as a vasoconstrictor in cardiopulmonary resuscitation (CPR) for patients with cardiopulmonary arrest (CPA); however, the Ep concentration in the serum of CPA patients is still unclear. The aim of this study was to evaluate the association between serum Ep levels and achieving the return of spontaneous circulation (ROSC) in out-of-hospital cardiac arrest (OHCA) patients with ventricular fibrillation (VF). Methods This was a prospective, observational clinical study involving OHCA patients with VF transferred to our hospital from July 2014 to July 2017. The measurement of serum catecholamines [Ep, norepinephrine (Nep), and dopamine (DOA)] and vasopressin [antidiuretic hormone (ADH)] levels was performed with blood samples obtained immediately upon patients' arrival at our hospital. Patients were classified into two groups: the ROSC(+) group and ROSC(−) group; the serum concentrations of catecholamines and ADH were compared between these two groups. Results The serum Ep and Nep levels were lower in the ROSC(+) group than those in the ROSC(−) group and the difference was statistically significant. On the other hand, no significant differences were found in serum DOA and ADH levels between the two groups. Conclusions The results of this study suggest that an increment in serum Ep levels does not promote achieving ROSC in OHCA patients with VF. Cureus 2023-08-10 /pmc/articles/PMC10491946/ /pubmed/37692701 http://dx.doi.org/10.7759/cureus.43252 Text en Copyright © 2023, Oshima et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Cardiology Oshima, Kiyohiro Sawada, Yusuke Isshiki, Yuta Ichikawa, Yumi Fukushima, Kazunori Aramaki, Yuto The Association Between Ventricular Fibrillation and Serum Catecholamine Levels |
title | The Association Between Ventricular Fibrillation and Serum Catecholamine Levels |
title_full | The Association Between Ventricular Fibrillation and Serum Catecholamine Levels |
title_fullStr | The Association Between Ventricular Fibrillation and Serum Catecholamine Levels |
title_full_unstemmed | The Association Between Ventricular Fibrillation and Serum Catecholamine Levels |
title_short | The Association Between Ventricular Fibrillation and Serum Catecholamine Levels |
title_sort | association between ventricular fibrillation and serum catecholamine levels |
topic | Cardiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491946/ https://www.ncbi.nlm.nih.gov/pubmed/37692701 http://dx.doi.org/10.7759/cureus.43252 |
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