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Lenalidomide-Induced Diffuse Alveolar Hemorrhage in Patient With Multiple Myeloma

We present a case of multiple myeloma that was treated with a regimen that included lenalidomide. Lenalidomide, a thalidomide analog, is an immunomodulatory drug created synthetically by changing the chemical makeup of thalidomide to increase efficacy and lessen negative effects. It has been authori...

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Autores principales: Qanash, Sultan, Alamoudi, Sameer, Alsuraihi, Anas, Jafri, Asif, Malakah, Manar A, Baghlaf, Bayan, Alamoudi, Mulukah, Althobaiti, Mohammad M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491948/
https://www.ncbi.nlm.nih.gov/pubmed/37692720
http://dx.doi.org/10.7759/cureus.43250
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author Qanash, Sultan
Alamoudi, Sameer
Alsuraihi, Anas
Jafri, Asif
Malakah, Manar A
Baghlaf, Bayan
Alamoudi, Mulukah
Althobaiti, Mohammad M
author_facet Qanash, Sultan
Alamoudi, Sameer
Alsuraihi, Anas
Jafri, Asif
Malakah, Manar A
Baghlaf, Bayan
Alamoudi, Mulukah
Althobaiti, Mohammad M
author_sort Qanash, Sultan
collection PubMed
description We present a case of multiple myeloma that was treated with a regimen that included lenalidomide. Lenalidomide, a thalidomide analog, is an immunomodulatory drug created synthetically by changing the chemical makeup of thalidomide to increase efficacy and lessen negative effects. It has been authorized for the treatment of relapsed or resistant multiple myeloma. In the case discussed in this report, the patient's lenalidomide dosage was changed to account for her renal impairment. Regardless of this adjustment of the dose, the patient presented with lung infiltrates, hemoptysis, and fever. Unfortunately, she was diagnosed with diffuse alveolar hemorrhage (DAH) secondary to lenalidomide after excluding other causes of hemoptysis. To the best of our knowledge, we believe this is the first case of DAH reported with lenalidomide in Saudi Arabia, which also discusses the possible therapeutic options for such presentations.
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spelling pubmed-104919482023-09-10 Lenalidomide-Induced Diffuse Alveolar Hemorrhage in Patient With Multiple Myeloma Qanash, Sultan Alamoudi, Sameer Alsuraihi, Anas Jafri, Asif Malakah, Manar A Baghlaf, Bayan Alamoudi, Mulukah Althobaiti, Mohammad M Cureus Oncology We present a case of multiple myeloma that was treated with a regimen that included lenalidomide. Lenalidomide, a thalidomide analog, is an immunomodulatory drug created synthetically by changing the chemical makeup of thalidomide to increase efficacy and lessen negative effects. It has been authorized for the treatment of relapsed or resistant multiple myeloma. In the case discussed in this report, the patient's lenalidomide dosage was changed to account for her renal impairment. Regardless of this adjustment of the dose, the patient presented with lung infiltrates, hemoptysis, and fever. Unfortunately, she was diagnosed with diffuse alveolar hemorrhage (DAH) secondary to lenalidomide after excluding other causes of hemoptysis. To the best of our knowledge, we believe this is the first case of DAH reported with lenalidomide in Saudi Arabia, which also discusses the possible therapeutic options for such presentations. Cureus 2023-08-09 /pmc/articles/PMC10491948/ /pubmed/37692720 http://dx.doi.org/10.7759/cureus.43250 Text en Copyright © 2023, Qanash et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Oncology
Qanash, Sultan
Alamoudi, Sameer
Alsuraihi, Anas
Jafri, Asif
Malakah, Manar A
Baghlaf, Bayan
Alamoudi, Mulukah
Althobaiti, Mohammad M
Lenalidomide-Induced Diffuse Alveolar Hemorrhage in Patient With Multiple Myeloma
title Lenalidomide-Induced Diffuse Alveolar Hemorrhage in Patient With Multiple Myeloma
title_full Lenalidomide-Induced Diffuse Alveolar Hemorrhage in Patient With Multiple Myeloma
title_fullStr Lenalidomide-Induced Diffuse Alveolar Hemorrhage in Patient With Multiple Myeloma
title_full_unstemmed Lenalidomide-Induced Diffuse Alveolar Hemorrhage in Patient With Multiple Myeloma
title_short Lenalidomide-Induced Diffuse Alveolar Hemorrhage in Patient With Multiple Myeloma
title_sort lenalidomide-induced diffuse alveolar hemorrhage in patient with multiple myeloma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491948/
https://www.ncbi.nlm.nih.gov/pubmed/37692720
http://dx.doi.org/10.7759/cureus.43250
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