Oncogenic MORC2 in cancer development and beyond

Microrchidia CW-type zinc finger 2 (MORC2) is a member of the MORC superfamily of nuclear proteins. Growing evidence has shown that MORC2 not only participates in gene transcription and chromatin remodeling but also plays a key in human disease and tumor development by regulating the expression of d...

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Detalles Bibliográficos
Autores principales: Zhang, Shan, Guo, Ayao, Wang, Huan, Liu, Jia, Dong, Chenshuang, Ren, Junyi, Wang, Guiling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491978/
https://www.ncbi.nlm.nih.gov/pubmed/37692502
http://dx.doi.org/10.1016/j.gendis.2023.05.010
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author Zhang, Shan
Guo, Ayao
Wang, Huan
Liu, Jia
Dong, Chenshuang
Ren, Junyi
Wang, Guiling
author_facet Zhang, Shan
Guo, Ayao
Wang, Huan
Liu, Jia
Dong, Chenshuang
Ren, Junyi
Wang, Guiling
author_sort Zhang, Shan
collection PubMed
description Microrchidia CW-type zinc finger 2 (MORC2) is a member of the MORC superfamily of nuclear proteins. Growing evidence has shown that MORC2 not only participates in gene transcription and chromatin remodeling but also plays a key in human disease and tumor development by regulating the expression of downstream oncogenes or tumor suppressors. The present review provides an updated overview of MORC2 in the aspect of cancer hallmark and therapeutic resistance and summarizes its upstream regulators and downstream target genes. This systematic review may provide a favorable theoretical basis for emerging players of MORC2 in tumor development and new insight into the potential clinical application of basic science discoveries in the future.
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spelling pubmed-104919782023-09-10 Oncogenic MORC2 in cancer development and beyond Zhang, Shan Guo, Ayao Wang, Huan Liu, Jia Dong, Chenshuang Ren, Junyi Wang, Guiling Genes Dis Review Article Microrchidia CW-type zinc finger 2 (MORC2) is a member of the MORC superfamily of nuclear proteins. Growing evidence has shown that MORC2 not only participates in gene transcription and chromatin remodeling but also plays a key in human disease and tumor development by regulating the expression of downstream oncogenes or tumor suppressors. The present review provides an updated overview of MORC2 in the aspect of cancer hallmark and therapeutic resistance and summarizes its upstream regulators and downstream target genes. This systematic review may provide a favorable theoretical basis for emerging players of MORC2 in tumor development and new insight into the potential clinical application of basic science discoveries in the future. Chongqing Medical University 2023-07-03 /pmc/articles/PMC10491978/ /pubmed/37692502 http://dx.doi.org/10.1016/j.gendis.2023.05.010 Text en © 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review Article
Zhang, Shan
Guo, Ayao
Wang, Huan
Liu, Jia
Dong, Chenshuang
Ren, Junyi
Wang, Guiling
Oncogenic MORC2 in cancer development and beyond
title Oncogenic MORC2 in cancer development and beyond
title_full Oncogenic MORC2 in cancer development and beyond
title_fullStr Oncogenic MORC2 in cancer development and beyond
title_full_unstemmed Oncogenic MORC2 in cancer development and beyond
title_short Oncogenic MORC2 in cancer development and beyond
title_sort oncogenic morc2 in cancer development and beyond
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491978/
https://www.ncbi.nlm.nih.gov/pubmed/37692502
http://dx.doi.org/10.1016/j.gendis.2023.05.010
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AT dongchenshuang oncogenicmorc2incancerdevelopmentandbeyond
AT renjunyi oncogenicmorc2incancerdevelopmentandbeyond
AT wangguiling oncogenicmorc2incancerdevelopmentandbeyond

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