The Pho23-Rpd3 histone deacetylase complex regulates the yeast metabolic transcription factor Stb5

Macroautophagy/autophagy is an essential catabolic process for maintaining homeostasis and cell survival under stressful conditions. We previously characterized the metabolic transcription factor Stb5 as a negative modulator of autophagy through its regulation of genes involved in NADPH production....

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Detalles Bibliográficos
Autores principales: Delorme-Axford, Elizabeth, Tasmi, Tabassum Ahmad, Klionsky, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2023
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492042/
https://www.ncbi.nlm.nih.gov/pubmed/37692089
http://dx.doi.org/10.17912/micropub.biology.000940
Descripción
Sumario:Macroautophagy/autophagy is an essential catabolic process for maintaining homeostasis and cell survival under stressful conditions. We previously characterized the metabolic transcription factor Stb5 as a negative modulator of autophagy through its regulation of genes involved in NADPH production. However, the molecular mechanisms regulating STB5 expression are not fully characterized. Here, we identify the yeast Pho23-Rpd3 histone deacetylase complex as a transcriptional regulator of STB5 . Our work provides insight into the mechanisms modulating the metabolic transcription factor Stb5 and expands on the repertoire of genes targeted by the Pho23-Rpd3 complex.

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