The Pho23-Rpd3 histone deacetylase complex regulates the yeast metabolic transcription factor Stb5

Macroautophagy/autophagy is an essential catabolic process for maintaining homeostasis and cell survival under stressful conditions. We previously characterized the metabolic transcription factor Stb5 as a negative modulator of autophagy through its regulation of genes involved in NADPH production....

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Autores principales: Delorme-Axford, Elizabeth, Tasmi, Tabassum Ahmad, Klionsky, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2023
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492042/
https://www.ncbi.nlm.nih.gov/pubmed/37692089
http://dx.doi.org/10.17912/micropub.biology.000940
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author Delorme-Axford, Elizabeth
Tasmi, Tabassum Ahmad
Klionsky, Daniel J.
author_facet Delorme-Axford, Elizabeth
Tasmi, Tabassum Ahmad
Klionsky, Daniel J.
author_sort Delorme-Axford, Elizabeth
collection PubMed
description Macroautophagy/autophagy is an essential catabolic process for maintaining homeostasis and cell survival under stressful conditions. We previously characterized the metabolic transcription factor Stb5 as a negative modulator of autophagy through its regulation of genes involved in NADPH production. However, the molecular mechanisms regulating STB5 expression are not fully characterized. Here, we identify the yeast Pho23-Rpd3 histone deacetylase complex as a transcriptional regulator of STB5 . Our work provides insight into the mechanisms modulating the metabolic transcription factor Stb5 and expands on the repertoire of genes targeted by the Pho23-Rpd3 complex.
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spelling pubmed-104920422023-09-10 The Pho23-Rpd3 histone deacetylase complex regulates the yeast metabolic transcription factor Stb5 Delorme-Axford, Elizabeth Tasmi, Tabassum Ahmad Klionsky, Daniel J. MicroPubl Biol New Finding Macroautophagy/autophagy is an essential catabolic process for maintaining homeostasis and cell survival under stressful conditions. We previously characterized the metabolic transcription factor Stb5 as a negative modulator of autophagy through its regulation of genes involved in NADPH production. However, the molecular mechanisms regulating STB5 expression are not fully characterized. Here, we identify the yeast Pho23-Rpd3 histone deacetylase complex as a transcriptional regulator of STB5 . Our work provides insight into the mechanisms modulating the metabolic transcription factor Stb5 and expands on the repertoire of genes targeted by the Pho23-Rpd3 complex. Caltech Library 2023-08-25 /pmc/articles/PMC10492042/ /pubmed/37692089 http://dx.doi.org/10.17912/micropub.biology.000940 Text en Copyright: © 2023 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle New Finding
Delorme-Axford, Elizabeth
Tasmi, Tabassum Ahmad
Klionsky, Daniel J.
The Pho23-Rpd3 histone deacetylase complex regulates the yeast metabolic transcription factor Stb5
title The Pho23-Rpd3 histone deacetylase complex regulates the yeast metabolic transcription factor Stb5
title_full The Pho23-Rpd3 histone deacetylase complex regulates the yeast metabolic transcription factor Stb5
title_fullStr The Pho23-Rpd3 histone deacetylase complex regulates the yeast metabolic transcription factor Stb5
title_full_unstemmed The Pho23-Rpd3 histone deacetylase complex regulates the yeast metabolic transcription factor Stb5
title_short The Pho23-Rpd3 histone deacetylase complex regulates the yeast metabolic transcription factor Stb5
title_sort pho23-rpd3 histone deacetylase complex regulates the yeast metabolic transcription factor stb5
topic New Finding
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492042/
https://www.ncbi.nlm.nih.gov/pubmed/37692089
http://dx.doi.org/10.17912/micropub.biology.000940
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