Solubility of lamotrigine in age-specific biorelevant media that simulated the fasted- and fed-conditions of the gastric and intestinal environments in pediatrics and adults: implications for traditional, re-formulated, modified, and new oral formulations

BACKGROUND: Lamotrigine is an effective antiseizure medication that can be used in the management of focal and generalized epilepsies in pediatric patients. This study was conducted to quantify and compare the solubility of lamotrigine in age-specific biorelevant media that simulated the fasted and...

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Detalles Bibliográficos
Autores principales: Shawahna, Ramzi, Saba’aneh, Hala, Daraghmeh, Amal, Qassarwi, Yara, Franco, Valentina, Declèves, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492362/
https://www.ncbi.nlm.nih.gov/pubmed/37684623
http://dx.doi.org/10.1186/s12896-023-00809-2

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