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Knowledge and perceptions about Dolutegravir and Dolutegravir counselling: a qualitative study among women living with HIV
INTRODUCTION: In 2018, the Malawi Ministry of Health adopted the recommendation to switch first-line antiretroviral therapy (ART) from an efavirenz (EFV)-based to a dolutegravir (DTG)-based regimen. Little is known about patients’ experience during this transition. We conducted a qualitative study t...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492391/ https://www.ncbi.nlm.nih.gov/pubmed/37689628 http://dx.doi.org/10.1186/s12905-023-02630-7 |
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author | Chapola, John C. Lee, Fan Bula, Agatha Rosenberg, Nora E. Tseka, Jennifer Chagomerana, Maganizo Hosseinipour, Mina C. Tang, Jennifer Hui-Yu |
author_facet | Chapola, John C. Lee, Fan Bula, Agatha Rosenberg, Nora E. Tseka, Jennifer Chagomerana, Maganizo Hosseinipour, Mina C. Tang, Jennifer Hui-Yu |
author_sort | Chapola, John C. |
collection | PubMed |
description | INTRODUCTION: In 2018, the Malawi Ministry of Health adopted the recommendation to switch first-line antiretroviral therapy (ART) from an efavirenz (EFV)-based to a dolutegravir (DTG)-based regimen. Little is known about patients’ experience during this transition. We conducted a qualitative study to explore DTG-related counselling challenges among providers of HIV care and factors influencing regimen switching or non-switching among women living with HIV in Lilongwe, Malawi. METHODS: Between February-July 2020, we recruited participants who took part in DTG counselling on reasons to switch, side effects, and benefits from two government health facilities providing HIV care: Area 18 health centre and Bwaila district hospital in Lilongwe, Malawi. We purposively sampled and interviewed 8 women living with HIV who remained on an EFV-based regimen after counselling, 10 women who switched to a DTG-based regimen, and 10 HIV care providers who provided counselling about ART switching. In-depth interviews were used to explore patient’s perceptions of DTG, factors affecting the decision to switch, and both patient and provider experience with counselling. Interview data was coded for themes using inductive and deductive codes. Interviews were conducted until thematic saturation was achieved. Data matrices were used for analysis and thematic extraction. RESULTS: Most women in both groups were well versed on DTG’s potential side effects and felt well counselled on the benefits of switching, such as quicker viral load suppression. Many women associated DTG with birth defects and expressed concern. However, the primary reason for not switching was concern with how the new medication would be tolerated, especially when they were satisfied with their current regimen. Almost all providers expressed difficulty providing DTG counselling. Primary reasons included feeling inadequately trained and/or not having resources to use during counselling, such as diagrams or brochures. CONCLUSION: DTG counselling was well accepted by women; however, some felt that their concerns were not fully addressed. Providers reflected this sentiment in that they did not feel adequately trained or well-equipped to provide adequate counselling. Training on counselling for new ART regimens should be intensified and utilize patient-centered educational materials to address the concerns raised by both patients and health care providers. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12905-023-02630-7. |
format | Online Article Text |
id | pubmed-10492391 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-104923912023-09-10 Knowledge and perceptions about Dolutegravir and Dolutegravir counselling: a qualitative study among women living with HIV Chapola, John C. Lee, Fan Bula, Agatha Rosenberg, Nora E. Tseka, Jennifer Chagomerana, Maganizo Hosseinipour, Mina C. Tang, Jennifer Hui-Yu BMC Womens Health Research INTRODUCTION: In 2018, the Malawi Ministry of Health adopted the recommendation to switch first-line antiretroviral therapy (ART) from an efavirenz (EFV)-based to a dolutegravir (DTG)-based regimen. Little is known about patients’ experience during this transition. We conducted a qualitative study to explore DTG-related counselling challenges among providers of HIV care and factors influencing regimen switching or non-switching among women living with HIV in Lilongwe, Malawi. METHODS: Between February-July 2020, we recruited participants who took part in DTG counselling on reasons to switch, side effects, and benefits from two government health facilities providing HIV care: Area 18 health centre and Bwaila district hospital in Lilongwe, Malawi. We purposively sampled and interviewed 8 women living with HIV who remained on an EFV-based regimen after counselling, 10 women who switched to a DTG-based regimen, and 10 HIV care providers who provided counselling about ART switching. In-depth interviews were used to explore patient’s perceptions of DTG, factors affecting the decision to switch, and both patient and provider experience with counselling. Interview data was coded for themes using inductive and deductive codes. Interviews were conducted until thematic saturation was achieved. Data matrices were used for analysis and thematic extraction. RESULTS: Most women in both groups were well versed on DTG’s potential side effects and felt well counselled on the benefits of switching, such as quicker viral load suppression. Many women associated DTG with birth defects and expressed concern. However, the primary reason for not switching was concern with how the new medication would be tolerated, especially when they were satisfied with their current regimen. Almost all providers expressed difficulty providing DTG counselling. Primary reasons included feeling inadequately trained and/or not having resources to use during counselling, such as diagrams or brochures. CONCLUSION: DTG counselling was well accepted by women; however, some felt that their concerns were not fully addressed. Providers reflected this sentiment in that they did not feel adequately trained or well-equipped to provide adequate counselling. Training on counselling for new ART regimens should be intensified and utilize patient-centered educational materials to address the concerns raised by both patients and health care providers. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12905-023-02630-7. BioMed Central 2023-09-09 /pmc/articles/PMC10492391/ /pubmed/37689628 http://dx.doi.org/10.1186/s12905-023-02630-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Chapola, John C. Lee, Fan Bula, Agatha Rosenberg, Nora E. Tseka, Jennifer Chagomerana, Maganizo Hosseinipour, Mina C. Tang, Jennifer Hui-Yu Knowledge and perceptions about Dolutegravir and Dolutegravir counselling: a qualitative study among women living with HIV |
title | Knowledge and perceptions about Dolutegravir and Dolutegravir counselling: a qualitative study among women living with HIV |
title_full | Knowledge and perceptions about Dolutegravir and Dolutegravir counselling: a qualitative study among women living with HIV |
title_fullStr | Knowledge and perceptions about Dolutegravir and Dolutegravir counselling: a qualitative study among women living with HIV |
title_full_unstemmed | Knowledge and perceptions about Dolutegravir and Dolutegravir counselling: a qualitative study among women living with HIV |
title_short | Knowledge and perceptions about Dolutegravir and Dolutegravir counselling: a qualitative study among women living with HIV |
title_sort | knowledge and perceptions about dolutegravir and dolutegravir counselling: a qualitative study among women living with hiv |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492391/ https://www.ncbi.nlm.nih.gov/pubmed/37689628 http://dx.doi.org/10.1186/s12905-023-02630-7 |
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