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Correlation between different levels and patterns of dyslipidemia and glomerular filtration rate in patients with type 2 diabetes: A cross‐sectional survey of a regional cohort
BACKGROUND: Due to the high cardiovascular risk in patients with diabetic nephropathy, more attention should be paid to lipid levels and dyslipidemia in these patients. The current study investigated the association between single and mixed dyslipidemia patterns, estimated glomerular filtration rate...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492450/ https://www.ncbi.nlm.nih.gov/pubmed/37537785 http://dx.doi.org/10.1002/jcla.24954 |
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author | Yadegar, Amirhossein Mohammadi, Fatemeh Rabizadeh, Soghra Ayati, Aryan Seyedi, Seyed Arsalan Nabipoorashrafi, Seyed Ali Esteghamati, Alireza Nakhjavani, Manouchehr |
author_facet | Yadegar, Amirhossein Mohammadi, Fatemeh Rabizadeh, Soghra Ayati, Aryan Seyedi, Seyed Arsalan Nabipoorashrafi, Seyed Ali Esteghamati, Alireza Nakhjavani, Manouchehr |
author_sort | Yadegar, Amirhossein |
collection | PubMed |
description | BACKGROUND: Due to the high cardiovascular risk in patients with diabetic nephropathy, more attention should be paid to lipid levels and dyslipidemia in these patients. The current study investigated the association between single and mixed dyslipidemia patterns, estimated glomerular filtration rate (eGFR), and different chronic kidney disease (CKD) stages. METHODS: This cross‐sectional study evaluated 4059 patients with type 2 diabetes (T2D). TG, TC, LDL‐C, and HDL‐C were measured. Non‐HDL‐C and AIP were calculated. We estimated eGFR using the CKD‐EPI equation. RESULTS: With the progression of the kidney failure stage, mean levels of TG, LDL‐C, non‐HDL‐C, and AIP decreased. HDL‐C levels decreased with the advance of the CKD stage in men but did not change significantly in women. The prevalence of single dyslipidemia, including high LDL‐C and high non‐HDL‐C, decreased with the advancing CKD stage. The prevalence of mixed dyslipidemia patterns, including high AIP and high LDL‐C, high AIP and high non‐HDL‐C, showed a significant downward tendency. TG and AIP levels were negatively, and HDL‐C levels were positively correlated with eGFR after adjusting for the risk factors. Also, CKD stage 3 was positively related to the risk of high TG and low HDL‐C. CONCLUSION: This study shows that blood lipids decreased with the progression of renal failure in patients with T2D. However, after adjustment, TG and AIP levels had negative, and HDL‐C levels had a positive correlation with eGFR, which could be consistent with the hypothesis that eGFR decreases with increasing TG or AIP levels or decreasing HDL‐C levels. |
format | Online Article Text |
id | pubmed-10492450 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104924502023-09-10 Correlation between different levels and patterns of dyslipidemia and glomerular filtration rate in patients with type 2 diabetes: A cross‐sectional survey of a regional cohort Yadegar, Amirhossein Mohammadi, Fatemeh Rabizadeh, Soghra Ayati, Aryan Seyedi, Seyed Arsalan Nabipoorashrafi, Seyed Ali Esteghamati, Alireza Nakhjavani, Manouchehr J Clin Lab Anal Research Articles BACKGROUND: Due to the high cardiovascular risk in patients with diabetic nephropathy, more attention should be paid to lipid levels and dyslipidemia in these patients. The current study investigated the association between single and mixed dyslipidemia patterns, estimated glomerular filtration rate (eGFR), and different chronic kidney disease (CKD) stages. METHODS: This cross‐sectional study evaluated 4059 patients with type 2 diabetes (T2D). TG, TC, LDL‐C, and HDL‐C were measured. Non‐HDL‐C and AIP were calculated. We estimated eGFR using the CKD‐EPI equation. RESULTS: With the progression of the kidney failure stage, mean levels of TG, LDL‐C, non‐HDL‐C, and AIP decreased. HDL‐C levels decreased with the advance of the CKD stage in men but did not change significantly in women. The prevalence of single dyslipidemia, including high LDL‐C and high non‐HDL‐C, decreased with the advancing CKD stage. The prevalence of mixed dyslipidemia patterns, including high AIP and high LDL‐C, high AIP and high non‐HDL‐C, showed a significant downward tendency. TG and AIP levels were negatively, and HDL‐C levels were positively correlated with eGFR after adjusting for the risk factors. Also, CKD stage 3 was positively related to the risk of high TG and low HDL‐C. CONCLUSION: This study shows that blood lipids decreased with the progression of renal failure in patients with T2D. However, after adjustment, TG and AIP levels had negative, and HDL‐C levels had a positive correlation with eGFR, which could be consistent with the hypothesis that eGFR decreases with increasing TG or AIP levels or decreasing HDL‐C levels. John Wiley and Sons Inc. 2023-08-03 /pmc/articles/PMC10492450/ /pubmed/37537785 http://dx.doi.org/10.1002/jcla.24954 Text en © 2023 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Yadegar, Amirhossein Mohammadi, Fatemeh Rabizadeh, Soghra Ayati, Aryan Seyedi, Seyed Arsalan Nabipoorashrafi, Seyed Ali Esteghamati, Alireza Nakhjavani, Manouchehr Correlation between different levels and patterns of dyslipidemia and glomerular filtration rate in patients with type 2 diabetes: A cross‐sectional survey of a regional cohort |
title | Correlation between different levels and patterns of dyslipidemia and glomerular filtration rate in patients with type 2 diabetes: A cross‐sectional survey of a regional cohort |
title_full | Correlation between different levels and patterns of dyslipidemia and glomerular filtration rate in patients with type 2 diabetes: A cross‐sectional survey of a regional cohort |
title_fullStr | Correlation between different levels and patterns of dyslipidemia and glomerular filtration rate in patients with type 2 diabetes: A cross‐sectional survey of a regional cohort |
title_full_unstemmed | Correlation between different levels and patterns of dyslipidemia and glomerular filtration rate in patients with type 2 diabetes: A cross‐sectional survey of a regional cohort |
title_short | Correlation between different levels and patterns of dyslipidemia and glomerular filtration rate in patients with type 2 diabetes: A cross‐sectional survey of a regional cohort |
title_sort | correlation between different levels and patterns of dyslipidemia and glomerular filtration rate in patients with type 2 diabetes: a cross‐sectional survey of a regional cohort |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492450/ https://www.ncbi.nlm.nih.gov/pubmed/37537785 http://dx.doi.org/10.1002/jcla.24954 |
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