Cargando…

Fructosamine is Not a Reliable Test for the Detection of Hyperglycemia: Insight from the Africans in America Study

OBJECTIVE: To improve detection of abnormal glucose tolerance (Abnl-GT), attention has moved beyond the oral glucose tolerance test (OGTT), to non-fasting markers of glycemia, specifically, HbA1c, fructosamine (FA) and glycated albumin (GA). Emerging data suggest that in African descent populations,...

Descripción completa

Detalles Bibliográficos
Autores principales: Gatete, Jean de Dieu, Worthy, Charlita C, Jagannathan, Ram, DuBose, Christopher W, Sacks, David B, Sumner, Anne E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492550/
https://www.ncbi.nlm.nih.gov/pubmed/37693326
http://dx.doi.org/10.2147/DMSO.S426406
_version_ 1785104280289542144
author Gatete, Jean de Dieu
Worthy, Charlita C
Jagannathan, Ram
DuBose, Christopher W
Sacks, David B
Sumner, Anne E
author_facet Gatete, Jean de Dieu
Worthy, Charlita C
Jagannathan, Ram
DuBose, Christopher W
Sacks, David B
Sumner, Anne E
author_sort Gatete, Jean de Dieu
collection PubMed
description OBJECTIVE: To improve detection of abnormal glucose tolerance (Abnl-GT), attention has moved beyond the oral glucose tolerance test (OGTT), to non-fasting markers of glycemia, specifically, HbA1c, fructosamine (FA) and glycated albumin (GA). Emerging data suggest that in African descent populations, the combination of HbA1c and GA is superior to the combination of HbA1c and FA. However, the diagnosis of Abnl-GT is usually based on tests which are performed only once. As reproducibility of Abnl-GT diagnosis by HbA1c, fructosamine (FA) and glycated albumin (GA) is unknown, reproducibility of Abnl-GT diagnosis by HbA1c, FA and GA were assessed in 209 African-born Blacks living in America. METHODS: At Visits 1 and 2 (9 ± 4 days apart), samples were obtained for HbA1c, FA and GA levels. Glucose tolerance status was determined at Visit 1 by OGTT. Reproducibility was based on the К-statistic and paired t-tests. Thresholds for the diagnosis of Abnl-GT by FA and GA which corresponded to an HbA1c of 5.7% were 235umol/L and 14.6%, respectively. RESULTS: Abnl-GT occurred in 38% (80/209). Diagnostic reproducibility was excellent for HbA1c (К≥0.86) and GA (К≥0.89), but only moderate for FA (К=0.59). Neither HbA1c nor GA levels varied between visits (both P≥0.3). In contrast, FA was significantly lower at Visit 2 than Visit 1(P<0.01). CONCLUSION: As HbA1c and GA provided similar diagnostic results on different days and FA did not, HbA1C and GA are superior to FA in both clinical care settings and epidemiologic studies.
format Online
Article
Text
id pubmed-10492550
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-104925502023-09-10 Fructosamine is Not a Reliable Test for the Detection of Hyperglycemia: Insight from the Africans in America Study Gatete, Jean de Dieu Worthy, Charlita C Jagannathan, Ram DuBose, Christopher W Sacks, David B Sumner, Anne E Diabetes Metab Syndr Obes Short Report OBJECTIVE: To improve detection of abnormal glucose tolerance (Abnl-GT), attention has moved beyond the oral glucose tolerance test (OGTT), to non-fasting markers of glycemia, specifically, HbA1c, fructosamine (FA) and glycated albumin (GA). Emerging data suggest that in African descent populations, the combination of HbA1c and GA is superior to the combination of HbA1c and FA. However, the diagnosis of Abnl-GT is usually based on tests which are performed only once. As reproducibility of Abnl-GT diagnosis by HbA1c, fructosamine (FA) and glycated albumin (GA) is unknown, reproducibility of Abnl-GT diagnosis by HbA1c, FA and GA were assessed in 209 African-born Blacks living in America. METHODS: At Visits 1 and 2 (9 ± 4 days apart), samples were obtained for HbA1c, FA and GA levels. Glucose tolerance status was determined at Visit 1 by OGTT. Reproducibility was based on the К-statistic and paired t-tests. Thresholds for the diagnosis of Abnl-GT by FA and GA which corresponded to an HbA1c of 5.7% were 235umol/L and 14.6%, respectively. RESULTS: Abnl-GT occurred in 38% (80/209). Diagnostic reproducibility was excellent for HbA1c (К≥0.86) and GA (К≥0.89), but only moderate for FA (К=0.59). Neither HbA1c nor GA levels varied between visits (both P≥0.3). In contrast, FA was significantly lower at Visit 2 than Visit 1(P<0.01). CONCLUSION: As HbA1c and GA provided similar diagnostic results on different days and FA did not, HbA1C and GA are superior to FA in both clinical care settings and epidemiologic studies. Dove 2023-09-05 /pmc/articles/PMC10492550/ /pubmed/37693326 http://dx.doi.org/10.2147/DMSO.S426406 Text en © 2023 Gatete et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Short Report
Gatete, Jean de Dieu
Worthy, Charlita C
Jagannathan, Ram
DuBose, Christopher W
Sacks, David B
Sumner, Anne E
Fructosamine is Not a Reliable Test for the Detection of Hyperglycemia: Insight from the Africans in America Study
title Fructosamine is Not a Reliable Test for the Detection of Hyperglycemia: Insight from the Africans in America Study
title_full Fructosamine is Not a Reliable Test for the Detection of Hyperglycemia: Insight from the Africans in America Study
title_fullStr Fructosamine is Not a Reliable Test for the Detection of Hyperglycemia: Insight from the Africans in America Study
title_full_unstemmed Fructosamine is Not a Reliable Test for the Detection of Hyperglycemia: Insight from the Africans in America Study
title_short Fructosamine is Not a Reliable Test for the Detection of Hyperglycemia: Insight from the Africans in America Study
title_sort fructosamine is not a reliable test for the detection of hyperglycemia: insight from the africans in america study
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492550/
https://www.ncbi.nlm.nih.gov/pubmed/37693326
http://dx.doi.org/10.2147/DMSO.S426406
work_keys_str_mv AT gatetejeandedieu fructosamineisnotareliabletestforthedetectionofhyperglycemiainsightfromtheafricansinamericastudy
AT worthycharlitac fructosamineisnotareliabletestforthedetectionofhyperglycemiainsightfromtheafricansinamericastudy
AT jagannathanram fructosamineisnotareliabletestforthedetectionofhyperglycemiainsightfromtheafricansinamericastudy
AT dubosechristopherw fructosamineisnotareliabletestforthedetectionofhyperglycemiainsightfromtheafricansinamericastudy
AT sacksdavidb fructosamineisnotareliabletestforthedetectionofhyperglycemiainsightfromtheafricansinamericastudy
AT sumnerannee fructosamineisnotareliabletestforthedetectionofhyperglycemiainsightfromtheafricansinamericastudy