A Case of Prolonged Fever in a Patient Infected With COVID-19 on Ofatumumab

We discuss a case of a 53-year-old woman with multiple sclerosis on monthly ofatumumab injections, who was infected with SARS-CoV-2 with persistent fevers for seven weeks. She was hospitalized for fever with diagnostic workup being unremarkable with negative SARS-CoV-2 IgM and undetectable nucleocap...

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Autores principales: Uddin, Yasin, Ramirez, Hector, Sheth, Monish A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492571/
https://www.ncbi.nlm.nih.gov/pubmed/37692739
http://dx.doi.org/10.7759/cureus.43274
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author Uddin, Yasin
Ramirez, Hector
Sheth, Monish A
author_facet Uddin, Yasin
Ramirez, Hector
Sheth, Monish A
author_sort Uddin, Yasin
collection PubMed
description We discuss a case of a 53-year-old woman with multiple sclerosis on monthly ofatumumab injections, who was infected with SARS-CoV-2 with persistent fevers for seven weeks. She was hospitalized for fever with diagnostic workup being unremarkable with negative SARS-CoV-2 IgM and undetectable nucleocapsid IgG antibodies four weeks out from the initial infection, indicating she may not have mounted an appropriate immune response to the infection. Patients on immunosuppression therapy may have a prolonged course of disease given that medications such as ofatumumab can take up to 24 weeks of B-cell recovery post-treatment discontinuation and a longer road to recovery.
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spelling pubmed-104925712023-09-10 A Case of Prolonged Fever in a Patient Infected With COVID-19 on Ofatumumab Uddin, Yasin Ramirez, Hector Sheth, Monish A Cureus Internal Medicine We discuss a case of a 53-year-old woman with multiple sclerosis on monthly ofatumumab injections, who was infected with SARS-CoV-2 with persistent fevers for seven weeks. She was hospitalized for fever with diagnostic workup being unremarkable with negative SARS-CoV-2 IgM and undetectable nucleocapsid IgG antibodies four weeks out from the initial infection, indicating she may not have mounted an appropriate immune response to the infection. Patients on immunosuppression therapy may have a prolonged course of disease given that medications such as ofatumumab can take up to 24 weeks of B-cell recovery post-treatment discontinuation and a longer road to recovery. Cureus 2023-08-10 /pmc/articles/PMC10492571/ /pubmed/37692739 http://dx.doi.org/10.7759/cureus.43274 Text en Copyright © 2023, Uddin et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Uddin, Yasin
Ramirez, Hector
Sheth, Monish A
A Case of Prolonged Fever in a Patient Infected With COVID-19 on Ofatumumab
title A Case of Prolonged Fever in a Patient Infected With COVID-19 on Ofatumumab
title_full A Case of Prolonged Fever in a Patient Infected With COVID-19 on Ofatumumab
title_fullStr A Case of Prolonged Fever in a Patient Infected With COVID-19 on Ofatumumab
title_full_unstemmed A Case of Prolonged Fever in a Patient Infected With COVID-19 on Ofatumumab
title_short A Case of Prolonged Fever in a Patient Infected With COVID-19 on Ofatumumab
title_sort case of prolonged fever in a patient infected with covid-19 on ofatumumab
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492571/
https://www.ncbi.nlm.nih.gov/pubmed/37692739
http://dx.doi.org/10.7759/cureus.43274
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