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Incidental Scleral Icterus in an Adolescent Male With Nausea: Clinical Diagnosis of Gilbert Syndrome in the Pediatric Outpatient Setting

Gilbert syndrome is a condition of non-hemolytic hyperbilirubinemia without further sequelae or primary laboratory abnormalities. Gilbert syndrome represents the most common hereditary disorder of bilirubin metabolism and is frequently identified as the etiology of familial jaundice in clinical medi...

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Autores principales: Gilman, Alex, Hatcher, Vishaka R, Hefelfinger, Donald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492650/
https://www.ncbi.nlm.nih.gov/pubmed/37692716
http://dx.doi.org/10.7759/cureus.43298
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author Gilman, Alex
Hatcher, Vishaka R
Hefelfinger, Donald
author_facet Gilman, Alex
Hatcher, Vishaka R
Hefelfinger, Donald
author_sort Gilman, Alex
collection PubMed
description Gilbert syndrome is a condition of non-hemolytic hyperbilirubinemia without further sequelae or primary laboratory abnormalities. Gilbert syndrome represents the most common hereditary disorder of bilirubin metabolism and is frequently identified as the etiology of familial jaundice in clinical medicine. This disorder typically manifests as mild unconjugated hyperbilirubinemia of benign nature. The diagnosis of Gilbert syndrome entails clinical assessment corroborated by the laboratory findings above in the absence of hemolysis or other organic liver diseases. We report a case of a 17-year-old boy who presented to a pediatric clinic with dyspepsia for the management of digestive symptoms, with clinical findings of mild scleral icterus and laboratory findings of isolated indirect hyperbilirubinemia. This case is unique in its subtlety of presentation. It highlights to trainees and experienced physicians the importance of the physical examination and targeted laboratory workup to arrive at the diagnosis of Gilbert syndrome.
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spelling pubmed-104926502023-09-10 Incidental Scleral Icterus in an Adolescent Male With Nausea: Clinical Diagnosis of Gilbert Syndrome in the Pediatric Outpatient Setting Gilman, Alex Hatcher, Vishaka R Hefelfinger, Donald Cureus Genetics Gilbert syndrome is a condition of non-hemolytic hyperbilirubinemia without further sequelae or primary laboratory abnormalities. Gilbert syndrome represents the most common hereditary disorder of bilirubin metabolism and is frequently identified as the etiology of familial jaundice in clinical medicine. This disorder typically manifests as mild unconjugated hyperbilirubinemia of benign nature. The diagnosis of Gilbert syndrome entails clinical assessment corroborated by the laboratory findings above in the absence of hemolysis or other organic liver diseases. We report a case of a 17-year-old boy who presented to a pediatric clinic with dyspepsia for the management of digestive symptoms, with clinical findings of mild scleral icterus and laboratory findings of isolated indirect hyperbilirubinemia. This case is unique in its subtlety of presentation. It highlights to trainees and experienced physicians the importance of the physical examination and targeted laboratory workup to arrive at the diagnosis of Gilbert syndrome. Cureus 2023-08-10 /pmc/articles/PMC10492650/ /pubmed/37692716 http://dx.doi.org/10.7759/cureus.43298 Text en Copyright © 2023, Gilman et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Genetics
Gilman, Alex
Hatcher, Vishaka R
Hefelfinger, Donald
Incidental Scleral Icterus in an Adolescent Male With Nausea: Clinical Diagnosis of Gilbert Syndrome in the Pediatric Outpatient Setting
title Incidental Scleral Icterus in an Adolescent Male With Nausea: Clinical Diagnosis of Gilbert Syndrome in the Pediatric Outpatient Setting
title_full Incidental Scleral Icterus in an Adolescent Male With Nausea: Clinical Diagnosis of Gilbert Syndrome in the Pediatric Outpatient Setting
title_fullStr Incidental Scleral Icterus in an Adolescent Male With Nausea: Clinical Diagnosis of Gilbert Syndrome in the Pediatric Outpatient Setting
title_full_unstemmed Incidental Scleral Icterus in an Adolescent Male With Nausea: Clinical Diagnosis of Gilbert Syndrome in the Pediatric Outpatient Setting
title_short Incidental Scleral Icterus in an Adolescent Male With Nausea: Clinical Diagnosis of Gilbert Syndrome in the Pediatric Outpatient Setting
title_sort incidental scleral icterus in an adolescent male with nausea: clinical diagnosis of gilbert syndrome in the pediatric outpatient setting
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492650/
https://www.ncbi.nlm.nih.gov/pubmed/37692716
http://dx.doi.org/10.7759/cureus.43298
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