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Incidental Scleral Icterus in an Adolescent Male With Nausea: Clinical Diagnosis of Gilbert Syndrome in the Pediatric Outpatient Setting
Gilbert syndrome is a condition of non-hemolytic hyperbilirubinemia without further sequelae or primary laboratory abnormalities. Gilbert syndrome represents the most common hereditary disorder of bilirubin metabolism and is frequently identified as the etiology of familial jaundice in clinical medi...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492650/ https://www.ncbi.nlm.nih.gov/pubmed/37692716 http://dx.doi.org/10.7759/cureus.43298 |
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author | Gilman, Alex Hatcher, Vishaka R Hefelfinger, Donald |
author_facet | Gilman, Alex Hatcher, Vishaka R Hefelfinger, Donald |
author_sort | Gilman, Alex |
collection | PubMed |
description | Gilbert syndrome is a condition of non-hemolytic hyperbilirubinemia without further sequelae or primary laboratory abnormalities. Gilbert syndrome represents the most common hereditary disorder of bilirubin metabolism and is frequently identified as the etiology of familial jaundice in clinical medicine. This disorder typically manifests as mild unconjugated hyperbilirubinemia of benign nature. The diagnosis of Gilbert syndrome entails clinical assessment corroborated by the laboratory findings above in the absence of hemolysis or other organic liver diseases. We report a case of a 17-year-old boy who presented to a pediatric clinic with dyspepsia for the management of digestive symptoms, with clinical findings of mild scleral icterus and laboratory findings of isolated indirect hyperbilirubinemia. This case is unique in its subtlety of presentation. It highlights to trainees and experienced physicians the importance of the physical examination and targeted laboratory workup to arrive at the diagnosis of Gilbert syndrome. |
format | Online Article Text |
id | pubmed-10492650 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-104926502023-09-10 Incidental Scleral Icterus in an Adolescent Male With Nausea: Clinical Diagnosis of Gilbert Syndrome in the Pediatric Outpatient Setting Gilman, Alex Hatcher, Vishaka R Hefelfinger, Donald Cureus Genetics Gilbert syndrome is a condition of non-hemolytic hyperbilirubinemia without further sequelae or primary laboratory abnormalities. Gilbert syndrome represents the most common hereditary disorder of bilirubin metabolism and is frequently identified as the etiology of familial jaundice in clinical medicine. This disorder typically manifests as mild unconjugated hyperbilirubinemia of benign nature. The diagnosis of Gilbert syndrome entails clinical assessment corroborated by the laboratory findings above in the absence of hemolysis or other organic liver diseases. We report a case of a 17-year-old boy who presented to a pediatric clinic with dyspepsia for the management of digestive symptoms, with clinical findings of mild scleral icterus and laboratory findings of isolated indirect hyperbilirubinemia. This case is unique in its subtlety of presentation. It highlights to trainees and experienced physicians the importance of the physical examination and targeted laboratory workup to arrive at the diagnosis of Gilbert syndrome. Cureus 2023-08-10 /pmc/articles/PMC10492650/ /pubmed/37692716 http://dx.doi.org/10.7759/cureus.43298 Text en Copyright © 2023, Gilman et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Genetics Gilman, Alex Hatcher, Vishaka R Hefelfinger, Donald Incidental Scleral Icterus in an Adolescent Male With Nausea: Clinical Diagnosis of Gilbert Syndrome in the Pediatric Outpatient Setting |
title | Incidental Scleral Icterus in an Adolescent Male With Nausea: Clinical Diagnosis of Gilbert Syndrome in the Pediatric Outpatient Setting |
title_full | Incidental Scleral Icterus in an Adolescent Male With Nausea: Clinical Diagnosis of Gilbert Syndrome in the Pediatric Outpatient Setting |
title_fullStr | Incidental Scleral Icterus in an Adolescent Male With Nausea: Clinical Diagnosis of Gilbert Syndrome in the Pediatric Outpatient Setting |
title_full_unstemmed | Incidental Scleral Icterus in an Adolescent Male With Nausea: Clinical Diagnosis of Gilbert Syndrome in the Pediatric Outpatient Setting |
title_short | Incidental Scleral Icterus in an Adolescent Male With Nausea: Clinical Diagnosis of Gilbert Syndrome in the Pediatric Outpatient Setting |
title_sort | incidental scleral icterus in an adolescent male with nausea: clinical diagnosis of gilbert syndrome in the pediatric outpatient setting |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492650/ https://www.ncbi.nlm.nih.gov/pubmed/37692716 http://dx.doi.org/10.7759/cureus.43298 |
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