Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility

The ketone body 3-hydroxybutyrate (3-OHB) increases cardiac output and myocardial perfusion without affecting blood pressure in humans, but the cardiovascular sites of action remain obscure. Here, we test the hypothesis in rats that 3-OHB acts directly on the heart to increase cardiac contractility...

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Detalles Bibliográficos
Autores principales: Homilius, Casper, Seefeldt, Jacob Marthinsen, Axelsen, Julie Sørensen, Pedersen, Tina Myhre, Sørensen, Trine Monberg, Nielsen, Roni, Wiggers, Henrik, Hansen, Jakob, Matchkov, Vladimir V., Bøtker, Hans Erik, Boedtkjer, Ebbe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Original Contribution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492777/
https://www.ncbi.nlm.nih.gov/pubmed/37688627
http://dx.doi.org/10.1007/s00395-023-01008-y

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