Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding

There is an arms race between beta-lactam antibiotics development and co-evolving beta-lactamases, which provide resistance by breaking down beta-lactam rings. We have observed that certain beta-lactamases tend to aggregate, which persists throughout their evolution under the selective pressure of a...

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Detalles Bibliográficos
Autores principales: Khodaparast, Ladan, Khodaparast, Laleh, Wu, Guiqin, Michiels, Emiel, Gallardo, Rodrigo, Houben, Bert, Garcia, Teresa, De Vleeschouwer, Matthias, Ramakers, Meine, Wilkinson, Hannah, Duran-Romaña, Ramon, Van Eldere, Johan, Rousseau, Frederic, Schymkowitz, Joost
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492782/
https://www.ncbi.nlm.nih.gov/pubmed/37689716
http://dx.doi.org/10.1038/s41467-023-41191-z

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