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Dominance vs epistasis: the biophysical origins and plasticity of genetic interactions within and between alleles
An important challenge in genetics, evolution and biotechnology is to understand and predict how mutations combine to alter phenotypes, including molecular activities, fitness and disease. In diploids, mutations in a gene can combine on the same chromosome or on different chromosomes as a “heteroall...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492795/ https://www.ncbi.nlm.nih.gov/pubmed/37689712 http://dx.doi.org/10.1038/s41467-023-41188-8 |