High throughput compound screening in neuronal cells identifies statins as activators of ataxin 3 expression

The spinocerebellar ataxias (SCA) comprise a group of inherited neurodegenerative diseases. SCA3 is the most common form, caused by the expansion of CAG repeats within the ataxin 3 (ATXN3) gene. The mutation results in the expression of an abnormal protein, containing long polyglutamine (polyQ) stre...

Descripción completa

Detalles Bibliográficos
Autores principales: Stahl, Fabian, Schmitt, Ina, Denner, Philip, de Boni, Laura, Wüllner, Ullrich, Breuer, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492798/
https://www.ncbi.nlm.nih.gov/pubmed/37689718
http://dx.doi.org/10.1038/s41598-023-41192-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492798/
https://www.ncbi.nlm.nih.gov/pubmed/37689718
http://dx.doi.org/10.1038/s41598-023-41192-4

Ejemplares similares