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Chemical-induced phase transition and global conformational reorganization of chromatin

Chemicals or drugs can accumulate within biomolecular condensates formed through phase separation in cells. Here, we use super-resolution imaging to search for chemicals that induce phase transition within chromatin at the microscale. This microscopic screening approach reveals that adriamycin (doxo...

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Detalles Bibliográficos
Autores principales:	Wang, Tengfei, Shi, Shuxiang, Shi, Yuanyuan, Jiang, Peipei, Hu, Ganlu, Ye, Qinying, Shi, Zhan, Yu, Kexin, Wang, Chenguang, Fan, Guoping, Zhao, Suwen, Ma, Hanhui, Chang, Alex C. Y., Li, Zhi, Bian, Qian, Lin, Chao-Po
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492836/ https://www.ncbi.nlm.nih.gov/pubmed/37689690 http://dx.doi.org/10.1038/s41467-023-41340-4

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