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Simulations of a protein fold switch reveal crowding-induced population shifts driven by disordered regions
Macromolecular crowding effects on globular proteins, which usually adopt a single stable fold, have been widely studied. However, little is known about crowding effects on fold-switching proteins, which reversibly switch between distinct folds. Here we study the mutationally driven switch between t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492864/ https://www.ncbi.nlm.nih.gov/pubmed/37689829 http://dx.doi.org/10.1038/s42004-023-00995-2 |