Cargando…

Effect of propolis on membrane bound enzymes linked with breast cancer

According to estimates from the World Health Organization [WHO], in 2020, 685000 people worldwide died and 2.3 million women were diagnosed with breast cancer. Breast cancer will be the most common cancer in the world by the end of 2020, when 7.8 million women will still be living who had received a...

Descripción completa

Detalles Bibliográficos
Autores principales: Thazhathuputhenpurayil, Sadhasivan Meghalatha, Natarajan, Muninathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492913/
https://www.ncbi.nlm.nih.gov/pubmed/37701506
http://dx.doi.org/10.6026/973206300181192
_version_ 1785104359523090432
author Thazhathuputhenpurayil, Sadhasivan Meghalatha
Natarajan, Muninathan
author_facet Thazhathuputhenpurayil, Sadhasivan Meghalatha
Natarajan, Muninathan
author_sort Thazhathuputhenpurayil, Sadhasivan Meghalatha
collection PubMed
description According to estimates from the World Health Organization [WHO], in 2020, 685000 people worldwide died and 2.3 million women were diagnosed with breast cancer. Breast cancer will be the most common cancer in the world by the end of 2020, when 7.8 million women will still be living who had received a diagnosis within the previous five years. The current study was formulated to note the effects of ethanolic extract of Propolis and Withaferin-A on Breast tumor initiation by benzo(a)pyrene [B(a)p], and its effects on ATPase enzyme levels. Na+/ K+-ATPase, Mg2+-ATPase, and calcium ATPase enzyme activities were decreased in the erythrocyte membrane and tissues of breast cancer-bearing animals compared with control groups. The levels of enzyme activities were near normal in Propolis treated animals. It wasapparent that the beneficial effect of Propolis was primarily exerted during the initiation and post-initiation stage of B(a)p-induced breast carcinogenesis. Overall, the data indicated that Propolis has modulating effects when administered intra-peritoneally on breast cancer-bearing animals.
format Online
Article
Text
id pubmed-10492913
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Biomedical Informatics
record_format MEDLINE/PubMed
spelling pubmed-104929132023-09-11 Effect of propolis on membrane bound enzymes linked with breast cancer Thazhathuputhenpurayil, Sadhasivan Meghalatha Natarajan, Muninathan Bioinformation Research Article According to estimates from the World Health Organization [WHO], in 2020, 685000 people worldwide died and 2.3 million women were diagnosed with breast cancer. Breast cancer will be the most common cancer in the world by the end of 2020, when 7.8 million women will still be living who had received a diagnosis within the previous five years. The current study was formulated to note the effects of ethanolic extract of Propolis and Withaferin-A on Breast tumor initiation by benzo(a)pyrene [B(a)p], and its effects on ATPase enzyme levels. Na+/ K+-ATPase, Mg2+-ATPase, and calcium ATPase enzyme activities were decreased in the erythrocyte membrane and tissues of breast cancer-bearing animals compared with control groups. The levels of enzyme activities were near normal in Propolis treated animals. It wasapparent that the beneficial effect of Propolis was primarily exerted during the initiation and post-initiation stage of B(a)p-induced breast carcinogenesis. Overall, the data indicated that Propolis has modulating effects when administered intra-peritoneally on breast cancer-bearing animals. Biomedical Informatics 2022-12-31 /pmc/articles/PMC10492913/ /pubmed/37701506 http://dx.doi.org/10.6026/973206300181192 Text en © 2022 Biomedical Informatics https://creativecommons.org/licenses/by/3.0/This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
spellingShingle Research Article
Thazhathuputhenpurayil, Sadhasivan Meghalatha
Natarajan, Muninathan
Effect of propolis on membrane bound enzymes linked with breast cancer
title Effect of propolis on membrane bound enzymes linked with breast cancer
title_full Effect of propolis on membrane bound enzymes linked with breast cancer
title_fullStr Effect of propolis on membrane bound enzymes linked with breast cancer
title_full_unstemmed Effect of propolis on membrane bound enzymes linked with breast cancer
title_short Effect of propolis on membrane bound enzymes linked with breast cancer
title_sort effect of propolis on membrane bound enzymes linked with breast cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492913/
https://www.ncbi.nlm.nih.gov/pubmed/37701506
http://dx.doi.org/10.6026/973206300181192
work_keys_str_mv AT thazhathuputhenpurayilsadhasivanmeghalatha effectofpropolisonmembraneboundenzymeslinkedwithbreastcancer
AT natarajanmuninathan effectofpropolisonmembraneboundenzymeslinkedwithbreastcancer