EZH2-mediated epigenetic silencing of tumor-suppressive let-7c/miR-99a cluster by hepatitis B virus X antigen enhances hepatocellular carcinoma progression and metastasis

BACKGROUND: Hepatitis B virus (HBV)-encoded X antigen, HBx, assists in the development of hepatocellular carcinoma (HCC) through complex mechanisms. Our results provide new insights into the EZH2 epigenetic repression of let-7c that promotes HCC migration induced by HBx. Thus, let-7c and HMGA2 repre...

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Detalles Bibliográficos
Autores principales: Wu, Chen-Shiou, Chien, Yi-Chung, Yen, Chia‐Jui, Wu, Jia-Yan, Bai, Li-Yuan, Yu, Yung-Luen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493019/
https://www.ncbi.nlm.nih.gov/pubmed/37689710
http://dx.doi.org/10.1186/s12935-023-03002-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493019/
https://www.ncbi.nlm.nih.gov/pubmed/37689710
http://dx.doi.org/10.1186/s12935-023-03002-9

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