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The SIRT7-mediated deacetylation of CHD1L amplifies HIF-2α-dependent signal that drives renal cell carcinoma progression and sunitinib resistance

BACKGROUND: Aberrant interplay between epigenetic reprogramming and hypoxia signaling contributes to renal cell carcinoma progression and drug resistance, which is an essential hallmark. How the chromatin remodelers enhance RCC malignancy remains to be poorly understood. We aimed to elucidate the ro...

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Detalles Bibliográficos
Autores principales:	He, Hongchao, Li, Jie, Wang, Wei, Cheng, Jie, Zhou, Jian, Li, Qunyi, Jin, Juan, Chen, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493023/ https://www.ncbi.nlm.nih.gov/pubmed/37691108 http://dx.doi.org/10.1186/s13578-023-01113-4

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