The current landscape of m6A modification in urological cancers

N6-methyladenosine (m6A) methylation is a dynamic and reversible procession of epigenetic modifications. It is increasingly recognized that m6A modification has been involved in the tumorigenesis, development, and progression of urological tumors. Emerging research explored the role of m6A modificat...

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Detalles Bibliográficos
Autores principales: Zeng, Yaohui, Lv, Cai, Wan, Bangbei, Gong, Binghao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2023
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493088/
https://www.ncbi.nlm.nih.gov/pubmed/37701836
http://dx.doi.org/10.7717/peerj.16023
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author Zeng, Yaohui
Lv, Cai
Wan, Bangbei
Gong, Binghao
author_facet Zeng, Yaohui
Lv, Cai
Wan, Bangbei
Gong, Binghao
author_sort Zeng, Yaohui
collection PubMed
description N6-methyladenosine (m6A) methylation is a dynamic and reversible procession of epigenetic modifications. It is increasingly recognized that m6A modification has been involved in the tumorigenesis, development, and progression of urological tumors. Emerging research explored the role of m6A modification in urological cancer. In this review, we will summarize the relationship between m6A modification, renal cell carcinoma, bladder cancer, and prostate cancer, and discover the biological function of m6A regulators in tumor cells. We will also discuss the possible mechanism and future application value used as a potential biomarker or therapeutic target to benefit patients with urological cancers.
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spelling pubmed-104930882023-09-11 The current landscape of m6A modification in urological cancers Zeng, Yaohui Lv, Cai Wan, Bangbei Gong, Binghao PeerJ Genetics N6-methyladenosine (m6A) methylation is a dynamic and reversible procession of epigenetic modifications. It is increasingly recognized that m6A modification has been involved in the tumorigenesis, development, and progression of urological tumors. Emerging research explored the role of m6A modification in urological cancer. In this review, we will summarize the relationship between m6A modification, renal cell carcinoma, bladder cancer, and prostate cancer, and discover the biological function of m6A regulators in tumor cells. We will also discuss the possible mechanism and future application value used as a potential biomarker or therapeutic target to benefit patients with urological cancers. PeerJ Inc. 2023-09-07 /pmc/articles/PMC10493088/ /pubmed/37701836 http://dx.doi.org/10.7717/peerj.16023 Text en ©2023 Zeng et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Genetics
Zeng, Yaohui
Lv, Cai
Wan, Bangbei
Gong, Binghao
The current landscape of m6A modification in urological cancers
title The current landscape of m6A modification in urological cancers
title_full The current landscape of m6A modification in urological cancers
title_fullStr The current landscape of m6A modification in urological cancers
title_full_unstemmed The current landscape of m6A modification in urological cancers
title_short The current landscape of m6A modification in urological cancers
title_sort current landscape of m6a modification in urological cancers
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493088/
https://www.ncbi.nlm.nih.gov/pubmed/37701836
http://dx.doi.org/10.7717/peerj.16023
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