The Treatment of Diffuse Large B-Cell Lymphoma (Triple Expression) Involving the Breast, Spleen, and Bone in a Male Patient with Viral Hepatitis B: A Rare Case Report

BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) involving the breast, spleen, and bone in a male patient with hepatitis B virus (HBV) infection is extremely rare in clinical practice. CASE PRESENTATION: We report a case of DLBCL involving the breast, spleen, and bone (triple expression of Bcl-2(+)...

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Autores principales: Zhou, Weiling, Gao, Qian, Wang, Lianjing, Li, Weijing, He, Cuiying, Li, Yanting, Feng, Lei, Liu, Wei, Liu, Lihong, Wang, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493155/
https://www.ncbi.nlm.nih.gov/pubmed/37700812
http://dx.doi.org/10.2147/CMAR.S427217
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author Zhou, Weiling
Gao, Qian
Wang, Lianjing
Li, Weijing
He, Cuiying
Li, Yanting
Feng, Lei
Liu, Wei
Liu, Lihong
Wang, Yuan
author_facet Zhou, Weiling
Gao, Qian
Wang, Lianjing
Li, Weijing
He, Cuiying
Li, Yanting
Feng, Lei
Liu, Wei
Liu, Lihong
Wang, Yuan
author_sort Zhou, Weiling
collection PubMed
description BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) involving the breast, spleen, and bone in a male patient with hepatitis B virus (HBV) infection is extremely rare in clinical practice. CASE PRESENTATION: We report a case of DLBCL involving the breast, spleen, and bone (triple expression of Bcl-2(+), Bcl-6(+), and 70% positive C-mcy) in a male patient with HBV admitted to our hospital. The patient was treated with EPOCH×4, lenalidomide+EPOCH×2 chemotherapy, intermittent methotrexate intrathecal injections to prevent central invasion, and autologous stem cell transplantation (ASCT). The patient is currently in complete remission, and the follow-up time was 43 months. CONCLUSION: A patient with DLBCL involving the breast, spleen, and bone can be treated with a combination of multiple regimens. If the patient’s economic conditions permit it, ASCT can be considered.
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spelling pubmed-104931552023-09-11 The Treatment of Diffuse Large B-Cell Lymphoma (Triple Expression) Involving the Breast, Spleen, and Bone in a Male Patient with Viral Hepatitis B: A Rare Case Report Zhou, Weiling Gao, Qian Wang, Lianjing Li, Weijing He, Cuiying Li, Yanting Feng, Lei Liu, Wei Liu, Lihong Wang, Yuan Cancer Manag Res Case Report BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) involving the breast, spleen, and bone in a male patient with hepatitis B virus (HBV) infection is extremely rare in clinical practice. CASE PRESENTATION: We report a case of DLBCL involving the breast, spleen, and bone (triple expression of Bcl-2(+), Bcl-6(+), and 70% positive C-mcy) in a male patient with HBV admitted to our hospital. The patient was treated with EPOCH×4, lenalidomide+EPOCH×2 chemotherapy, intermittent methotrexate intrathecal injections to prevent central invasion, and autologous stem cell transplantation (ASCT). The patient is currently in complete remission, and the follow-up time was 43 months. CONCLUSION: A patient with DLBCL involving the breast, spleen, and bone can be treated with a combination of multiple regimens. If the patient’s economic conditions permit it, ASCT can be considered. Dove 2023-09-06 /pmc/articles/PMC10493155/ /pubmed/37700812 http://dx.doi.org/10.2147/CMAR.S427217 Text en © 2023 Zhou et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Report
Zhou, Weiling
Gao, Qian
Wang, Lianjing
Li, Weijing
He, Cuiying
Li, Yanting
Feng, Lei
Liu, Wei
Liu, Lihong
Wang, Yuan
The Treatment of Diffuse Large B-Cell Lymphoma (Triple Expression) Involving the Breast, Spleen, and Bone in a Male Patient with Viral Hepatitis B: A Rare Case Report
title The Treatment of Diffuse Large B-Cell Lymphoma (Triple Expression) Involving the Breast, Spleen, and Bone in a Male Patient with Viral Hepatitis B: A Rare Case Report
title_full The Treatment of Diffuse Large B-Cell Lymphoma (Triple Expression) Involving the Breast, Spleen, and Bone in a Male Patient with Viral Hepatitis B: A Rare Case Report
title_fullStr The Treatment of Diffuse Large B-Cell Lymphoma (Triple Expression) Involving the Breast, Spleen, and Bone in a Male Patient with Viral Hepatitis B: A Rare Case Report
title_full_unstemmed The Treatment of Diffuse Large B-Cell Lymphoma (Triple Expression) Involving the Breast, Spleen, and Bone in a Male Patient with Viral Hepatitis B: A Rare Case Report
title_short The Treatment of Diffuse Large B-Cell Lymphoma (Triple Expression) Involving the Breast, Spleen, and Bone in a Male Patient with Viral Hepatitis B: A Rare Case Report
title_sort treatment of diffuse large b-cell lymphoma (triple expression) involving the breast, spleen, and bone in a male patient with viral hepatitis b: a rare case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493155/
https://www.ncbi.nlm.nih.gov/pubmed/37700812
http://dx.doi.org/10.2147/CMAR.S427217
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