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Nanoparticles and cytokine response
Synthetic nanoparticles (NPs) are non-viral equivalents of viral gene delivery systems that are actively explored to deliver a spectrum of nucleic acids for diverse range of therapies. The success of the nanoparticulate delivery systems, in the form of efficacy and safety, depends on various factors...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493271/ https://www.ncbi.nlm.nih.gov/pubmed/37701495 http://dx.doi.org/10.3389/fbioe.2023.1243651 |
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author | Nasrullah, Mohammad Meenakshi Sundaram, Daniel Nisakar Claerhout, Jillian Ha, Khanh Demirkaya, Erkan Uludag, Hasan |
author_facet | Nasrullah, Mohammad Meenakshi Sundaram, Daniel Nisakar Claerhout, Jillian Ha, Khanh Demirkaya, Erkan Uludag, Hasan |
author_sort | Nasrullah, Mohammad |
collection | PubMed |
description | Synthetic nanoparticles (NPs) are non-viral equivalents of viral gene delivery systems that are actively explored to deliver a spectrum of nucleic acids for diverse range of therapies. The success of the nanoparticulate delivery systems, in the form of efficacy and safety, depends on various factors related to the physicochemical features of the NPs, as well as their ability to remain “stealth” in the host environment. The initial cytokine response upon exposure to nucleic acid bearing NPs is a critical component of the host response and, unless desired, should be minimized to prevent the unintended consequences of NP administration. In this review article, we will summarize the most recent literature on cytokine responses to nanoparticulate delivery systems and identify the main factors affecting this response. The NP features responsible for eliciting the cytokine response are articulated along with other factors related to the mode of therapeutic administration. For diseases arising from altered cytokine pathophysiology, attempts to silence the individual components of cytokine response are summarized in the context of different diseases, and the roles of NP features on this respect are presented. We finish with the authors’ perspective on the possibility of engineering NP systems with controlled cytokine responses. This review is intended to sensitize the reader with important issues related to cytokine elicitation of non-viral NPs and the means of controlling them to design improved interventions in the clinical setting. |
format | Online Article Text |
id | pubmed-10493271 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104932712023-09-12 Nanoparticles and cytokine response Nasrullah, Mohammad Meenakshi Sundaram, Daniel Nisakar Claerhout, Jillian Ha, Khanh Demirkaya, Erkan Uludag, Hasan Front Bioeng Biotechnol Bioengineering and Biotechnology Synthetic nanoparticles (NPs) are non-viral equivalents of viral gene delivery systems that are actively explored to deliver a spectrum of nucleic acids for diverse range of therapies. The success of the nanoparticulate delivery systems, in the form of efficacy and safety, depends on various factors related to the physicochemical features of the NPs, as well as their ability to remain “stealth” in the host environment. The initial cytokine response upon exposure to nucleic acid bearing NPs is a critical component of the host response and, unless desired, should be minimized to prevent the unintended consequences of NP administration. In this review article, we will summarize the most recent literature on cytokine responses to nanoparticulate delivery systems and identify the main factors affecting this response. The NP features responsible for eliciting the cytokine response are articulated along with other factors related to the mode of therapeutic administration. For diseases arising from altered cytokine pathophysiology, attempts to silence the individual components of cytokine response are summarized in the context of different diseases, and the roles of NP features on this respect are presented. We finish with the authors’ perspective on the possibility of engineering NP systems with controlled cytokine responses. This review is intended to sensitize the reader with important issues related to cytokine elicitation of non-viral NPs and the means of controlling them to design improved interventions in the clinical setting. Frontiers Media S.A. 2023-08-28 /pmc/articles/PMC10493271/ /pubmed/37701495 http://dx.doi.org/10.3389/fbioe.2023.1243651 Text en Copyright © 2023 Nasrullah, Meenakshi Sundaram, Claerhout, Ha, Demirkaya and Uludag. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Nasrullah, Mohammad Meenakshi Sundaram, Daniel Nisakar Claerhout, Jillian Ha, Khanh Demirkaya, Erkan Uludag, Hasan Nanoparticles and cytokine response |
title | Nanoparticles and cytokine response |
title_full | Nanoparticles and cytokine response |
title_fullStr | Nanoparticles and cytokine response |
title_full_unstemmed | Nanoparticles and cytokine response |
title_short | Nanoparticles and cytokine response |
title_sort | nanoparticles and cytokine response |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493271/ https://www.ncbi.nlm.nih.gov/pubmed/37701495 http://dx.doi.org/10.3389/fbioe.2023.1243651 |
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