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Nanoparticles and cytokine response

Synthetic nanoparticles (NPs) are non-viral equivalents of viral gene delivery systems that are actively explored to deliver a spectrum of nucleic acids for diverse range of therapies. The success of the nanoparticulate delivery systems, in the form of efficacy and safety, depends on various factors...

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Autores principales: Nasrullah, Mohammad, Meenakshi Sundaram, Daniel Nisakar, Claerhout, Jillian, Ha, Khanh, Demirkaya, Erkan, Uludag, Hasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493271/
https://www.ncbi.nlm.nih.gov/pubmed/37701495
http://dx.doi.org/10.3389/fbioe.2023.1243651
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author Nasrullah, Mohammad
Meenakshi Sundaram, Daniel Nisakar
Claerhout, Jillian
Ha, Khanh
Demirkaya, Erkan
Uludag, Hasan
author_facet Nasrullah, Mohammad
Meenakshi Sundaram, Daniel Nisakar
Claerhout, Jillian
Ha, Khanh
Demirkaya, Erkan
Uludag, Hasan
author_sort Nasrullah, Mohammad
collection PubMed
description Synthetic nanoparticles (NPs) are non-viral equivalents of viral gene delivery systems that are actively explored to deliver a spectrum of nucleic acids for diverse range of therapies. The success of the nanoparticulate delivery systems, in the form of efficacy and safety, depends on various factors related to the physicochemical features of the NPs, as well as their ability to remain “stealth” in the host environment. The initial cytokine response upon exposure to nucleic acid bearing NPs is a critical component of the host response and, unless desired, should be minimized to prevent the unintended consequences of NP administration. In this review article, we will summarize the most recent literature on cytokine responses to nanoparticulate delivery systems and identify the main factors affecting this response. The NP features responsible for eliciting the cytokine response are articulated along with other factors related to the mode of therapeutic administration. For diseases arising from altered cytokine pathophysiology, attempts to silence the individual components of cytokine response are summarized in the context of different diseases, and the roles of NP features on this respect are presented. We finish with the authors’ perspective on the possibility of engineering NP systems with controlled cytokine responses. This review is intended to sensitize the reader with important issues related to cytokine elicitation of non-viral NPs and the means of controlling them to design improved interventions in the clinical setting.
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spelling pubmed-104932712023-09-12 Nanoparticles and cytokine response Nasrullah, Mohammad Meenakshi Sundaram, Daniel Nisakar Claerhout, Jillian Ha, Khanh Demirkaya, Erkan Uludag, Hasan Front Bioeng Biotechnol Bioengineering and Biotechnology Synthetic nanoparticles (NPs) are non-viral equivalents of viral gene delivery systems that are actively explored to deliver a spectrum of nucleic acids for diverse range of therapies. The success of the nanoparticulate delivery systems, in the form of efficacy and safety, depends on various factors related to the physicochemical features of the NPs, as well as their ability to remain “stealth” in the host environment. The initial cytokine response upon exposure to nucleic acid bearing NPs is a critical component of the host response and, unless desired, should be minimized to prevent the unintended consequences of NP administration. In this review article, we will summarize the most recent literature on cytokine responses to nanoparticulate delivery systems and identify the main factors affecting this response. The NP features responsible for eliciting the cytokine response are articulated along with other factors related to the mode of therapeutic administration. For diseases arising from altered cytokine pathophysiology, attempts to silence the individual components of cytokine response are summarized in the context of different diseases, and the roles of NP features on this respect are presented. We finish with the authors’ perspective on the possibility of engineering NP systems with controlled cytokine responses. This review is intended to sensitize the reader with important issues related to cytokine elicitation of non-viral NPs and the means of controlling them to design improved interventions in the clinical setting. Frontiers Media S.A. 2023-08-28 /pmc/articles/PMC10493271/ /pubmed/37701495 http://dx.doi.org/10.3389/fbioe.2023.1243651 Text en Copyright © 2023 Nasrullah, Meenakshi Sundaram, Claerhout, Ha, Demirkaya and Uludag. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Nasrullah, Mohammad
Meenakshi Sundaram, Daniel Nisakar
Claerhout, Jillian
Ha, Khanh
Demirkaya, Erkan
Uludag, Hasan
Nanoparticles and cytokine response
title Nanoparticles and cytokine response
title_full Nanoparticles and cytokine response
title_fullStr Nanoparticles and cytokine response
title_full_unstemmed Nanoparticles and cytokine response
title_short Nanoparticles and cytokine response
title_sort nanoparticles and cytokine response
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493271/
https://www.ncbi.nlm.nih.gov/pubmed/37701495
http://dx.doi.org/10.3389/fbioe.2023.1243651
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