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Developing brain under renewed attack: viral infection during pregnancy

Living in a globalized world, viral infections such as CHIKV, SARS-COV-2, and ZIKV have become inevitable to also infect the most vulnerable groups in our society. That poses a danger to these populations including pregnant women since the developing brain is sensitive to maternal stressors includin...

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Detalles Bibliográficos
Autores principales: Recaioglu, Hatice, Kolk, Sharon M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493316/
https://www.ncbi.nlm.nih.gov/pubmed/37700750
http://dx.doi.org/10.3389/fnins.2023.1119943
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author Recaioglu, Hatice
Kolk, Sharon M.
author_facet Recaioglu, Hatice
Kolk, Sharon M.
author_sort Recaioglu, Hatice
collection PubMed
description Living in a globalized world, viral infections such as CHIKV, SARS-COV-2, and ZIKV have become inevitable to also infect the most vulnerable groups in our society. That poses a danger to these populations including pregnant women since the developing brain is sensitive to maternal stressors including viral infections. Upon maternal infection, the viruses can gain access to the fetus via the maternofetal barrier and even to the fetal brain during which factors such as viral receptor expression, time of infection, and the balance between antiviral immune responses and pro-viral mechanisms contribute to mother-to-fetus transmission and fetal infection. Both the direct pro-viral mechanisms and the resulting dysregulated immune response can cause multi-level impairment in the maternofetal and brain barriers and the developing brain itself leading to dysfunction or even loss of several cell populations. Thus, maternal viral infections can disturb brain development and even predispose to neurodevelopmental disorders. In this review, we discuss the potential contribution of maternal viral infections of three relevant relative recent players in the field: Zika, Chikungunya, and Severe Acute Respiratory Syndrome Coronavirus-2, to the impairment of brain development throughout the entire route.
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spelling pubmed-104933162023-09-12 Developing brain under renewed attack: viral infection during pregnancy Recaioglu, Hatice Kolk, Sharon M. Front Neurosci Neuroscience Living in a globalized world, viral infections such as CHIKV, SARS-COV-2, and ZIKV have become inevitable to also infect the most vulnerable groups in our society. That poses a danger to these populations including pregnant women since the developing brain is sensitive to maternal stressors including viral infections. Upon maternal infection, the viruses can gain access to the fetus via the maternofetal barrier and even to the fetal brain during which factors such as viral receptor expression, time of infection, and the balance between antiviral immune responses and pro-viral mechanisms contribute to mother-to-fetus transmission and fetal infection. Both the direct pro-viral mechanisms and the resulting dysregulated immune response can cause multi-level impairment in the maternofetal and brain barriers and the developing brain itself leading to dysfunction or even loss of several cell populations. Thus, maternal viral infections can disturb brain development and even predispose to neurodevelopmental disorders. In this review, we discuss the potential contribution of maternal viral infections of three relevant relative recent players in the field: Zika, Chikungunya, and Severe Acute Respiratory Syndrome Coronavirus-2, to the impairment of brain development throughout the entire route. Frontiers Media S.A. 2023-08-28 /pmc/articles/PMC10493316/ /pubmed/37700750 http://dx.doi.org/10.3389/fnins.2023.1119943 Text en Copyright © 2023 Recaioglu and Kolk. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Recaioglu, Hatice
Kolk, Sharon M.
Developing brain under renewed attack: viral infection during pregnancy
title Developing brain under renewed attack: viral infection during pregnancy
title_full Developing brain under renewed attack: viral infection during pregnancy
title_fullStr Developing brain under renewed attack: viral infection during pregnancy
title_full_unstemmed Developing brain under renewed attack: viral infection during pregnancy
title_short Developing brain under renewed attack: viral infection during pregnancy
title_sort developing brain under renewed attack: viral infection during pregnancy
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493316/
https://www.ncbi.nlm.nih.gov/pubmed/37700750
http://dx.doi.org/10.3389/fnins.2023.1119943
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