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Optimization of a small molecule inhibitor of secondary nucleation in α-synuclein aggregation

Parkinson’s disease is characterised by the deposition in the brain of amyloid aggregates of α-synuclein. The surfaces of these amyloid aggregates can catalyse the formation of new aggregates, giving rise to a positive feedback mechanism responsible for the rapid proliferation of α-synuclein deposit...

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Detalles Bibliográficos
Autores principales:	Staats, Roxine, Brotzakis, Z. Faidon, Chia, Sean, Horne, Robert I., Vendruscolo, Michele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493395/ https://www.ncbi.nlm.nih.gov/pubmed/37701726 http://dx.doi.org/10.3389/fmolb.2023.1155753

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