Zinc defends against Parthanatos and promotes functional recovery after spinal cord injury through SIRT3‐mediated anti‐oxidative stress and mitophagy

INTRODUCTION: Spinal cord injury (SCI) is a central nervous system injury that is primarily traumatic and manifests as motor, sensory, and autonomic dysfunction below the level of damage. Our previous studies confirmed the ability of zinc to protect mitochondria, protect neurons and promote spinal c...

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Autores principales: Jiang, Dingyuan, Yang, Xu, Ge, Minghao, Hu, Hengshuo, Xu, Chang, Wen, Shan, Deng, Hao, Mei, Xifan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493669/
https://www.ncbi.nlm.nih.gov/pubmed/37063066
http://dx.doi.org/10.1111/cns.14222
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author Jiang, Dingyuan
Yang, Xu
Ge, Minghao
Hu, Hengshuo
Xu, Chang
Wen, Shan
Deng, Hao
Mei, Xifan
author_facet Jiang, Dingyuan
Yang, Xu
Ge, Minghao
Hu, Hengshuo
Xu, Chang
Wen, Shan
Deng, Hao
Mei, Xifan
author_sort Jiang, Dingyuan
collection PubMed
description INTRODUCTION: Spinal cord injury (SCI) is a central nervous system injury that is primarily traumatic and manifests as motor, sensory, and autonomic dysfunction below the level of damage. Our previous studies confirmed the ability of zinc to protect mitochondria, protect neurons and promote spinal cord recovery. However, the role of zinc in Parthanatos is unknown. AIM: We investigated the effects of zinc in Parthanatos from oxidative stress and mitophagy. We elucidated the role of SIRT3 in providing new ideas for treating spinal cord injury. THE RESULTS: Zinc protected SCI mice by regulating Parthanatos. On the one hand, zinc eliminated ROS directly through SIRT3 deacetylation targeting SOD2 to alleviate Parthanatos. On the other hand, zinc eliminated ROS indirectly through SIRT3‐mediated promotion of mitophagy to alleviate Parthanatos. CONCLUSION: Zinc defends against Parthanatos and promotes functional recovery after spinal cord injury through SIRT3‐mediated anti‐oxidative stress and mitophagy.
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spelling pubmed-104936692023-09-12 Zinc defends against Parthanatos and promotes functional recovery after spinal cord injury through SIRT3‐mediated anti‐oxidative stress and mitophagy Jiang, Dingyuan Yang, Xu Ge, Minghao Hu, Hengshuo Xu, Chang Wen, Shan Deng, Hao Mei, Xifan CNS Neurosci Ther Original Articles INTRODUCTION: Spinal cord injury (SCI) is a central nervous system injury that is primarily traumatic and manifests as motor, sensory, and autonomic dysfunction below the level of damage. Our previous studies confirmed the ability of zinc to protect mitochondria, protect neurons and promote spinal cord recovery. However, the role of zinc in Parthanatos is unknown. AIM: We investigated the effects of zinc in Parthanatos from oxidative stress and mitophagy. We elucidated the role of SIRT3 in providing new ideas for treating spinal cord injury. THE RESULTS: Zinc protected SCI mice by regulating Parthanatos. On the one hand, zinc eliminated ROS directly through SIRT3 deacetylation targeting SOD2 to alleviate Parthanatos. On the other hand, zinc eliminated ROS indirectly through SIRT3‐mediated promotion of mitophagy to alleviate Parthanatos. CONCLUSION: Zinc defends against Parthanatos and promotes functional recovery after spinal cord injury through SIRT3‐mediated anti‐oxidative stress and mitophagy. John Wiley and Sons Inc. 2023-04-17 /pmc/articles/PMC10493669/ /pubmed/37063066 http://dx.doi.org/10.1111/cns.14222 Text en © 2023 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Jiang, Dingyuan
Yang, Xu
Ge, Minghao
Hu, Hengshuo
Xu, Chang
Wen, Shan
Deng, Hao
Mei, Xifan
Zinc defends against Parthanatos and promotes functional recovery after spinal cord injury through SIRT3‐mediated anti‐oxidative stress and mitophagy
title Zinc defends against Parthanatos and promotes functional recovery after spinal cord injury through SIRT3‐mediated anti‐oxidative stress and mitophagy
title_full Zinc defends against Parthanatos and promotes functional recovery after spinal cord injury through SIRT3‐mediated anti‐oxidative stress and mitophagy
title_fullStr Zinc defends against Parthanatos and promotes functional recovery after spinal cord injury through SIRT3‐mediated anti‐oxidative stress and mitophagy
title_full_unstemmed Zinc defends against Parthanatos and promotes functional recovery after spinal cord injury through SIRT3‐mediated anti‐oxidative stress and mitophagy
title_short Zinc defends against Parthanatos and promotes functional recovery after spinal cord injury through SIRT3‐mediated anti‐oxidative stress and mitophagy
title_sort zinc defends against parthanatos and promotes functional recovery after spinal cord injury through sirt3‐mediated anti‐oxidative stress and mitophagy
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493669/
https://www.ncbi.nlm.nih.gov/pubmed/37063066
http://dx.doi.org/10.1111/cns.14222
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