Preferential pruning of inhibitory synapses by microglia contributes to alteration of the balance between excitatory and inhibitory synapses in the hippocampus in temporal lobe epilepsy

BACKGROUND: A consensus has formed that neural circuits in the brain underlie the pathogenesis of temporal lobe epilepsy (TLE). In particular, the synaptic excitation/inhibition balance (E/I balance) has been implicated in shifting towards elevated excitation during the development of TLE. METHODS:...

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Detalles Bibliográficos
Autores principales: Fan, Jianchen, Dong, Xinyan, Tang, Yejiao, Wang, Xuehui, Lin, Donghui, Gong, Lifen, Chen, Chen, Jiang, Jie, Shen, Weida, Xu, Anyu, Zhang, Xiangnan, Xie, Yicheng, Huang, Xin, Zeng, Linghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493672/
https://www.ncbi.nlm.nih.gov/pubmed/37072932
http://dx.doi.org/10.1111/cns.14224

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