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Glucosinolate-rich broccoli sprouts protect against oxidative stress and improve adaptations to intense exercise training

Oxidative stress plays a vital role for the adaptive responses to physical training. However, excessive oxidative stress can precipitate cellular damage, necessitating protective mechanisms to mitigate this effect. Glucosinolates, found predominantly in cruciferous vegetables, can be converted into...

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Autores principales: Flockhart, M., Nilsson, L.C., Tillqvist, E.N., Vinge, F., Millbert, F., Lännerström, J., Nilsson, P.H., Samyn, D., Apró, W., Sundqvist, M.L., Larsen, F.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493800/
https://www.ncbi.nlm.nih.gov/pubmed/37688976
http://dx.doi.org/10.1016/j.redox.2023.102873
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author Flockhart, M.
Nilsson, L.C.
Tillqvist, E.N.
Vinge, F.
Millbert, F.
Lännerström, J.
Nilsson, P.H.
Samyn, D.
Apró, W.
Sundqvist, M.L.
Larsen, F.J.
author_facet Flockhart, M.
Nilsson, L.C.
Tillqvist, E.N.
Vinge, F.
Millbert, F.
Lännerström, J.
Nilsson, P.H.
Samyn, D.
Apró, W.
Sundqvist, M.L.
Larsen, F.J.
author_sort Flockhart, M.
collection PubMed
description Oxidative stress plays a vital role for the adaptive responses to physical training. However, excessive oxidative stress can precipitate cellular damage, necessitating protective mechanisms to mitigate this effect. Glucosinolates, found predominantly in cruciferous vegetables, can be converted into isothiocyanates, known for their antioxidative properties. These compounds activate crucial antioxidant defence pathways and support mitochondrial function and protein integrity under oxidative stress, in both Nrf2-dependent and independent manners. We here administered glucosinolate-rich broccoli sprouts (GRS), in a randomized double-blinded cross-over fashion to 9 healthy subjects in combination with daily intense exercise training for 7 days. We found that exercise in combination with GRS significantly decreased the levels of carbonylated proteins in skeletal muscle and the release of myeloperoxidase into blood. Moreover, it lowered lactate accumulation during submaximal exercise, and attenuated the severe nocturnal hypoglycaemic episodes seen during the placebo condition. Furthermore, GRS in combination with exercise improved physical performance, which was unchanged in the placebo condition.
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spelling pubmed-104938002023-09-12 Glucosinolate-rich broccoli sprouts protect against oxidative stress and improve adaptations to intense exercise training Flockhart, M. Nilsson, L.C. Tillqvist, E.N. Vinge, F. Millbert, F. Lännerström, J. Nilsson, P.H. Samyn, D. Apró, W. Sundqvist, M.L. Larsen, F.J. Redox Biol Research Paper Oxidative stress plays a vital role for the adaptive responses to physical training. However, excessive oxidative stress can precipitate cellular damage, necessitating protective mechanisms to mitigate this effect. Glucosinolates, found predominantly in cruciferous vegetables, can be converted into isothiocyanates, known for their antioxidative properties. These compounds activate crucial antioxidant defence pathways and support mitochondrial function and protein integrity under oxidative stress, in both Nrf2-dependent and independent manners. We here administered glucosinolate-rich broccoli sprouts (GRS), in a randomized double-blinded cross-over fashion to 9 healthy subjects in combination with daily intense exercise training for 7 days. We found that exercise in combination with GRS significantly decreased the levels of carbonylated proteins in skeletal muscle and the release of myeloperoxidase into blood. Moreover, it lowered lactate accumulation during submaximal exercise, and attenuated the severe nocturnal hypoglycaemic episodes seen during the placebo condition. Furthermore, GRS in combination with exercise improved physical performance, which was unchanged in the placebo condition. Elsevier 2023-09-03 /pmc/articles/PMC10493800/ /pubmed/37688976 http://dx.doi.org/10.1016/j.redox.2023.102873 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Research Paper
Flockhart, M.
Nilsson, L.C.
Tillqvist, E.N.
Vinge, F.
Millbert, F.
Lännerström, J.
Nilsson, P.H.
Samyn, D.
Apró, W.
Sundqvist, M.L.
Larsen, F.J.
Glucosinolate-rich broccoli sprouts protect against oxidative stress and improve adaptations to intense exercise training
title Glucosinolate-rich broccoli sprouts protect against oxidative stress and improve adaptations to intense exercise training
title_full Glucosinolate-rich broccoli sprouts protect against oxidative stress and improve adaptations to intense exercise training
title_fullStr Glucosinolate-rich broccoli sprouts protect against oxidative stress and improve adaptations to intense exercise training
title_full_unstemmed Glucosinolate-rich broccoli sprouts protect against oxidative stress and improve adaptations to intense exercise training
title_short Glucosinolate-rich broccoli sprouts protect against oxidative stress and improve adaptations to intense exercise training
title_sort glucosinolate-rich broccoli sprouts protect against oxidative stress and improve adaptations to intense exercise training
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493800/
https://www.ncbi.nlm.nih.gov/pubmed/37688976
http://dx.doi.org/10.1016/j.redox.2023.102873
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