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The interplay between previous infection and mental health condition on antibody response to COVID-19 mRNA vaccination

Increasing evidence has been pointing towards the existence of a bi-directional interplay between mental health condition and immunity. Data collected during the COVID-19 outbreak suggest that depressive symptoms may impact the production of antibodies against SARS-CoV-2, while a previous infection...

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Autores principales: Grignoli, Nicola, Petrocchi, Serena, Polito, Andrea, Gagliano, Vanessa, Sallusto, Federica, Uguccioni, Mariagrazia, Gabutti, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493882/
https://www.ncbi.nlm.nih.gov/pubmed/37701787
http://dx.doi.org/10.1016/j.bbih.2023.100677
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author Grignoli, Nicola
Petrocchi, Serena
Polito, Andrea
Gagliano, Vanessa
Sallusto, Federica
Uguccioni, Mariagrazia
Gabutti, Luca
author_facet Grignoli, Nicola
Petrocchi, Serena
Polito, Andrea
Gagliano, Vanessa
Sallusto, Federica
Uguccioni, Mariagrazia
Gabutti, Luca
author_sort Grignoli, Nicola
collection PubMed
description Increasing evidence has been pointing towards the existence of a bi-directional interplay between mental health condition and immunity. Data collected during the COVID-19 outbreak suggest that depressive symptoms may impact the production of antibodies against SARS-CoV-2, while a previous infection could affect the immune response and cause neuropsychological disturbances. A prospective observational study was designed to investigate the association between mental health conditions and immune response over time. We analyzed the mental health at baseline and the antibodies before and after immunization with the COVID-19 mRNA vaccine in a cohort of healthcare professionals in southern Switzerland. One-hundred and six subjects were enrolled. Anxiety, distress and depression correlated to each other. There were no correlations between the mentioned variables and the vaccine induced IgG antibodies against the receptor binding domain (RBD) of the spike protein. For those who had a previous COVID-19 infection, the antibodies increased according to the grade of depression. For those who did not, the anti-RBD IgG levels remained similar when comparing presence or absence of depression symptoms. Our results show that previous SARS-CoV-2 natural infection in subjects with mental health conditions enhances the immune response to COVID-19 mRNA vaccination. The correlation between immune response to COVID-19 vaccination, a previous exposure to the virus, and symptoms of mood disorders, makes it necessary to explore the direction of the causality between immune response and depressive symptoms.
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spelling pubmed-104938822023-09-12 The interplay between previous infection and mental health condition on antibody response to COVID-19 mRNA vaccination Grignoli, Nicola Petrocchi, Serena Polito, Andrea Gagliano, Vanessa Sallusto, Federica Uguccioni, Mariagrazia Gabutti, Luca Brain Behav Immun Health Full Length Article Increasing evidence has been pointing towards the existence of a bi-directional interplay between mental health condition and immunity. Data collected during the COVID-19 outbreak suggest that depressive symptoms may impact the production of antibodies against SARS-CoV-2, while a previous infection could affect the immune response and cause neuropsychological disturbances. A prospective observational study was designed to investigate the association between mental health conditions and immune response over time. We analyzed the mental health at baseline and the antibodies before and after immunization with the COVID-19 mRNA vaccine in a cohort of healthcare professionals in southern Switzerland. One-hundred and six subjects were enrolled. Anxiety, distress and depression correlated to each other. There were no correlations between the mentioned variables and the vaccine induced IgG antibodies against the receptor binding domain (RBD) of the spike protein. For those who had a previous COVID-19 infection, the antibodies increased according to the grade of depression. For those who did not, the anti-RBD IgG levels remained similar when comparing presence or absence of depression symptoms. Our results show that previous SARS-CoV-2 natural infection in subjects with mental health conditions enhances the immune response to COVID-19 mRNA vaccination. The correlation between immune response to COVID-19 vaccination, a previous exposure to the virus, and symptoms of mood disorders, makes it necessary to explore the direction of the causality between immune response and depressive symptoms. Elsevier 2023-08-25 /pmc/articles/PMC10493882/ /pubmed/37701787 http://dx.doi.org/10.1016/j.bbih.2023.100677 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Full Length Article
Grignoli, Nicola
Petrocchi, Serena
Polito, Andrea
Gagliano, Vanessa
Sallusto, Federica
Uguccioni, Mariagrazia
Gabutti, Luca
The interplay between previous infection and mental health condition on antibody response to COVID-19 mRNA vaccination
title The interplay between previous infection and mental health condition on antibody response to COVID-19 mRNA vaccination
title_full The interplay between previous infection and mental health condition on antibody response to COVID-19 mRNA vaccination
title_fullStr The interplay between previous infection and mental health condition on antibody response to COVID-19 mRNA vaccination
title_full_unstemmed The interplay between previous infection and mental health condition on antibody response to COVID-19 mRNA vaccination
title_short The interplay between previous infection and mental health condition on antibody response to COVID-19 mRNA vaccination
title_sort interplay between previous infection and mental health condition on antibody response to covid-19 mrna vaccination
topic Full Length Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493882/
https://www.ncbi.nlm.nih.gov/pubmed/37701787
http://dx.doi.org/10.1016/j.bbih.2023.100677
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