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Extending arterial stiffness assessment along the circumference using beam-steered ARFI and wave-tracking: A proof-of-principle study in phantoms and ex vivo
BACKGROUND: To fully quantify arterial wall and plaque stiffness, acoustic radiation force impulse (ARFI)-induced wave-tracking along the entire vessel circumference is desired. However, attenuation and guided wave behavior in thin vessel walls limits wave-tracking to short trajectories. This study...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Research Network of Computational and Structural Biotechnology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493891/ https://www.ncbi.nlm.nih.gov/pubmed/37701019 http://dx.doi.org/10.1016/j.csbj.2023.08.024 |
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author | Pruijssen, Judith T. Fekkes, Stein Menssen, Jan de Korte, Chris L. Hansen, Hendrik H.G. |
author_facet | Pruijssen, Judith T. Fekkes, Stein Menssen, Jan de Korte, Chris L. Hansen, Hendrik H.G. |
author_sort | Pruijssen, Judith T. |
collection | PubMed |
description | BACKGROUND: To fully quantify arterial wall and plaque stiffness, acoustic radiation force impulse (ARFI)-induced wave-tracking along the entire vessel circumference is desired. However, attenuation and guided wave behavior in thin vessel walls limits wave-tracking to short trajectories. This study investigated the potential of beam-steered ARFI and wave-tracking to extend group velocity estimation over a larger proportion of the circumference compared to conventional 0° ARFI-induced wave-tracking. METHODS: Seven vessel-mimicking polyvinyl alcohol cryogel phantoms with various dimensions and compositions and an ex vivo human carotid artery were imaged in a dedicated setup. For every 20⁰ phantom rotation, transverse group wave velocity measurements were performed with an Aixplorer Ultimate system and SL18–5 transducer using 0⁰/20⁰/−20⁰-angled ultrasound pushes. Transmural angular wave velocities were derived along 60⁰-trajectories. A 360⁰-angular velocity map was composed from the top-wall 60⁰-trajectories 0°-data, averaged over all physical phantom rotations (reference). For each phantom rotation, 360⁰-angular velocity maps were composed using 0°-data (0⁰-approach) or data from all angles (beam-steered approach). Percentages of rotations with visible waves and relative angular velocity errors compared to the reference map as function of the circumferential angle were determined for both approaches. RESULTS: Reference 360°-angular velocity maps could be derived for all samples, representing their stiffness. Beam-steering decreased the proportion of the circumference where waves were untraceable by 20% in phantoms and 10% ex vivo, mainly at 0° push locations. Relative errors were similar for both approaches (phantoms: 10–15%, ex vivo: 15–35%). CONCLUSION: Beam-steering enables wave-tracking along a higher proportion of the wall circumference than 0⁰ ARFI-induced wave-tracking. |
format | Online Article Text |
id | pubmed-10493891 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Research Network of Computational and Structural Biotechnology |
record_format | MEDLINE/PubMed |
spelling | pubmed-104938912023-09-12 Extending arterial stiffness assessment along the circumference using beam-steered ARFI and wave-tracking: A proof-of-principle study in phantoms and ex vivo Pruijssen, Judith T. Fekkes, Stein Menssen, Jan de Korte, Chris L. Hansen, Hendrik H.G. Comput Struct Biotechnol J Research Article BACKGROUND: To fully quantify arterial wall and plaque stiffness, acoustic radiation force impulse (ARFI)-induced wave-tracking along the entire vessel circumference is desired. However, attenuation and guided wave behavior in thin vessel walls limits wave-tracking to short trajectories. This study investigated the potential of beam-steered ARFI and wave-tracking to extend group velocity estimation over a larger proportion of the circumference compared to conventional 0° ARFI-induced wave-tracking. METHODS: Seven vessel-mimicking polyvinyl alcohol cryogel phantoms with various dimensions and compositions and an ex vivo human carotid artery were imaged in a dedicated setup. For every 20⁰ phantom rotation, transverse group wave velocity measurements were performed with an Aixplorer Ultimate system and SL18–5 transducer using 0⁰/20⁰/−20⁰-angled ultrasound pushes. Transmural angular wave velocities were derived along 60⁰-trajectories. A 360⁰-angular velocity map was composed from the top-wall 60⁰-trajectories 0°-data, averaged over all physical phantom rotations (reference). For each phantom rotation, 360⁰-angular velocity maps were composed using 0°-data (0⁰-approach) or data from all angles (beam-steered approach). Percentages of rotations with visible waves and relative angular velocity errors compared to the reference map as function of the circumferential angle were determined for both approaches. RESULTS: Reference 360°-angular velocity maps could be derived for all samples, representing their stiffness. Beam-steering decreased the proportion of the circumference where waves were untraceable by 20% in phantoms and 10% ex vivo, mainly at 0° push locations. Relative errors were similar for both approaches (phantoms: 10–15%, ex vivo: 15–35%). CONCLUSION: Beam-steering enables wave-tracking along a higher proportion of the wall circumference than 0⁰ ARFI-induced wave-tracking. Research Network of Computational and Structural Biotechnology 2023-08-26 /pmc/articles/PMC10493891/ /pubmed/37701019 http://dx.doi.org/10.1016/j.csbj.2023.08.024 Text en © 2023 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Pruijssen, Judith T. Fekkes, Stein Menssen, Jan de Korte, Chris L. Hansen, Hendrik H.G. Extending arterial stiffness assessment along the circumference using beam-steered ARFI and wave-tracking: A proof-of-principle study in phantoms and ex vivo |
title | Extending arterial stiffness assessment along the circumference using beam-steered ARFI and wave-tracking: A proof-of-principle study in phantoms and ex vivo |
title_full | Extending arterial stiffness assessment along the circumference using beam-steered ARFI and wave-tracking: A proof-of-principle study in phantoms and ex vivo |
title_fullStr | Extending arterial stiffness assessment along the circumference using beam-steered ARFI and wave-tracking: A proof-of-principle study in phantoms and ex vivo |
title_full_unstemmed | Extending arterial stiffness assessment along the circumference using beam-steered ARFI and wave-tracking: A proof-of-principle study in phantoms and ex vivo |
title_short | Extending arterial stiffness assessment along the circumference using beam-steered ARFI and wave-tracking: A proof-of-principle study in phantoms and ex vivo |
title_sort | extending arterial stiffness assessment along the circumference using beam-steered arfi and wave-tracking: a proof-of-principle study in phantoms and ex vivo |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493891/ https://www.ncbi.nlm.nih.gov/pubmed/37701019 http://dx.doi.org/10.1016/j.csbj.2023.08.024 |
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