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Acute Stress Modulates Social Approach and Social Maintenance in Adult Zebrafish

Stress alters social functioning in a complex manner. An important variable determining the final effects of stress is stressor intensity. However, the precise relationship between stressor intensity and social behavior is not well understood. Here, we investigate the effects of varying acute stress...

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Autores principales: Cook, Alexander, Beckmann, Holger, Azap, Rutkay, Ryu, Soojin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493981/
https://www.ncbi.nlm.nih.gov/pubmed/37620148
http://dx.doi.org/10.1523/ENEURO.0491-22.2023
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author Cook, Alexander
Beckmann, Holger
Azap, Rutkay
Ryu, Soojin
author_facet Cook, Alexander
Beckmann, Holger
Azap, Rutkay
Ryu, Soojin
author_sort Cook, Alexander
collection PubMed
description Stress alters social functioning in a complex manner. An important variable determining the final effects of stress is stressor intensity. However, the precise relationship between stressor intensity and social behavior is not well understood. Here, we investigate the effects of varying acute stressor intensity exposure on social behavior using adult zebrafish. We first establish a novel test using adult zebrafish that allows distinguishing fish’s drive to approach a social cue and its ability to engage and maintain social interaction within the same behavioral paradigm. Next, we combined this test with a new method to deliver an acute stress stimulus of varying intensities. Our results show that both social approach and social maintenance are reduced in adult zebrafish on acute stress exposure in an intensity-dependent manner. Interestingly, lower stress intensity reduces social maintenance without affecting the social approach, while a higher stress level is required to alter social approach. These results provide evidence for a direct correlation between acute stressor intensity and social functioning and suggest that distinct steps in social behavior are modulated differentially by the acute stress level.
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spelling pubmed-104939812023-09-12 Acute Stress Modulates Social Approach and Social Maintenance in Adult Zebrafish Cook, Alexander Beckmann, Holger Azap, Rutkay Ryu, Soojin eNeuro Research Article: New Research Stress alters social functioning in a complex manner. An important variable determining the final effects of stress is stressor intensity. However, the precise relationship between stressor intensity and social behavior is not well understood. Here, we investigate the effects of varying acute stressor intensity exposure on social behavior using adult zebrafish. We first establish a novel test using adult zebrafish that allows distinguishing fish’s drive to approach a social cue and its ability to engage and maintain social interaction within the same behavioral paradigm. Next, we combined this test with a new method to deliver an acute stress stimulus of varying intensities. Our results show that both social approach and social maintenance are reduced in adult zebrafish on acute stress exposure in an intensity-dependent manner. Interestingly, lower stress intensity reduces social maintenance without affecting the social approach, while a higher stress level is required to alter social approach. These results provide evidence for a direct correlation between acute stressor intensity and social functioning and suggest that distinct steps in social behavior are modulated differentially by the acute stress level. Society for Neuroscience 2023-09-08 /pmc/articles/PMC10493981/ /pubmed/37620148 http://dx.doi.org/10.1523/ENEURO.0491-22.2023 Text en Copyright © 2023 Cook et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Research Article: New Research
Cook, Alexander
Beckmann, Holger
Azap, Rutkay
Ryu, Soojin
Acute Stress Modulates Social Approach and Social Maintenance in Adult Zebrafish
title Acute Stress Modulates Social Approach and Social Maintenance in Adult Zebrafish
title_full Acute Stress Modulates Social Approach and Social Maintenance in Adult Zebrafish
title_fullStr Acute Stress Modulates Social Approach and Social Maintenance in Adult Zebrafish
title_full_unstemmed Acute Stress Modulates Social Approach and Social Maintenance in Adult Zebrafish
title_short Acute Stress Modulates Social Approach and Social Maintenance in Adult Zebrafish
title_sort acute stress modulates social approach and social maintenance in adult zebrafish
topic Research Article: New Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493981/
https://www.ncbi.nlm.nih.gov/pubmed/37620148
http://dx.doi.org/10.1523/ENEURO.0491-22.2023
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