Cargando…
Acute Stress Modulates Social Approach and Social Maintenance in Adult Zebrafish
Stress alters social functioning in a complex manner. An important variable determining the final effects of stress is stressor intensity. However, the precise relationship between stressor intensity and social behavior is not well understood. Here, we investigate the effects of varying acute stress...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Neuroscience
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493981/ https://www.ncbi.nlm.nih.gov/pubmed/37620148 http://dx.doi.org/10.1523/ENEURO.0491-22.2023 |
_version_ | 1785104587875680256 |
---|---|
author | Cook, Alexander Beckmann, Holger Azap, Rutkay Ryu, Soojin |
author_facet | Cook, Alexander Beckmann, Holger Azap, Rutkay Ryu, Soojin |
author_sort | Cook, Alexander |
collection | PubMed |
description | Stress alters social functioning in a complex manner. An important variable determining the final effects of stress is stressor intensity. However, the precise relationship between stressor intensity and social behavior is not well understood. Here, we investigate the effects of varying acute stressor intensity exposure on social behavior using adult zebrafish. We first establish a novel test using adult zebrafish that allows distinguishing fish’s drive to approach a social cue and its ability to engage and maintain social interaction within the same behavioral paradigm. Next, we combined this test with a new method to deliver an acute stress stimulus of varying intensities. Our results show that both social approach and social maintenance are reduced in adult zebrafish on acute stress exposure in an intensity-dependent manner. Interestingly, lower stress intensity reduces social maintenance without affecting the social approach, while a higher stress level is required to alter social approach. These results provide evidence for a direct correlation between acute stressor intensity and social functioning and suggest that distinct steps in social behavior are modulated differentially by the acute stress level. |
format | Online Article Text |
id | pubmed-10493981 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Society for Neuroscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-104939812023-09-12 Acute Stress Modulates Social Approach and Social Maintenance in Adult Zebrafish Cook, Alexander Beckmann, Holger Azap, Rutkay Ryu, Soojin eNeuro Research Article: New Research Stress alters social functioning in a complex manner. An important variable determining the final effects of stress is stressor intensity. However, the precise relationship between stressor intensity and social behavior is not well understood. Here, we investigate the effects of varying acute stressor intensity exposure on social behavior using adult zebrafish. We first establish a novel test using adult zebrafish that allows distinguishing fish’s drive to approach a social cue and its ability to engage and maintain social interaction within the same behavioral paradigm. Next, we combined this test with a new method to deliver an acute stress stimulus of varying intensities. Our results show that both social approach and social maintenance are reduced in adult zebrafish on acute stress exposure in an intensity-dependent manner. Interestingly, lower stress intensity reduces social maintenance without affecting the social approach, while a higher stress level is required to alter social approach. These results provide evidence for a direct correlation between acute stressor intensity and social functioning and suggest that distinct steps in social behavior are modulated differentially by the acute stress level. Society for Neuroscience 2023-09-08 /pmc/articles/PMC10493981/ /pubmed/37620148 http://dx.doi.org/10.1523/ENEURO.0491-22.2023 Text en Copyright © 2023 Cook et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Research Article: New Research Cook, Alexander Beckmann, Holger Azap, Rutkay Ryu, Soojin Acute Stress Modulates Social Approach and Social Maintenance in Adult Zebrafish |
title | Acute Stress Modulates Social Approach and Social Maintenance in Adult Zebrafish |
title_full | Acute Stress Modulates Social Approach and Social Maintenance in Adult Zebrafish |
title_fullStr | Acute Stress Modulates Social Approach and Social Maintenance in Adult Zebrafish |
title_full_unstemmed | Acute Stress Modulates Social Approach and Social Maintenance in Adult Zebrafish |
title_short | Acute Stress Modulates Social Approach and Social Maintenance in Adult Zebrafish |
title_sort | acute stress modulates social approach and social maintenance in adult zebrafish |
topic | Research Article: New Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10493981/ https://www.ncbi.nlm.nih.gov/pubmed/37620148 http://dx.doi.org/10.1523/ENEURO.0491-22.2023 |
work_keys_str_mv | AT cookalexander acutestressmodulatessocialapproachandsocialmaintenanceinadultzebrafish AT beckmannholger acutestressmodulatessocialapproachandsocialmaintenanceinadultzebrafish AT azaprutkay acutestressmodulatessocialapproachandsocialmaintenanceinadultzebrafish AT ryusoojin acutestressmodulatessocialapproachandsocialmaintenanceinadultzebrafish |