Transcriptomic profiling and longitudinal study reveal the relationship of anti-MDA5 titer and type I IFN signature in MDA5+ dermatomyositis

OBJECTIVE: This study aimed to investigate the relationship between anti-MDA5 titer and type I IFN signature in patients with MDA5+ DM. METHODS: We explored the transcriptome profiling of PBMCs in MDA5+ DM patients with high-titer of antibody at disease onset or relapse and normal low-titer after tr...

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Detalles Bibliográficos
Autores principales: Wang, Yan, Jia, Hongxia, Li, Wei, Liu, Hongping, Tu, Meng, Li, Jing, Cheng, Jiuling, Zhang, Guojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494241/
https://www.ncbi.nlm.nih.gov/pubmed/37701443
http://dx.doi.org/10.3389/fimmu.2023.1249844

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