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Multifunctional nanocomposites modulating the tumor microenvironment for enhanced cancer immunotherapy

Cancer immunotherapy has gained momentum for treating malignant tumors over the past decade. Checkpoint blockade and chimeric antigen receptor cell therapy (CAR-T) have shown considerable potency against liquid and solid cancers. However, the tumor microenvironment (TME) is highly immunosuppressive...

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Detalles Bibliográficos
Autores principales: Sharma, Prashant, Otto, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494322/
https://www.ncbi.nlm.nih.gov/pubmed/37701452
http://dx.doi.org/10.1016/j.bioactmat.2023.08.022
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author Sharma, Prashant
Otto, Mario
author_facet Sharma, Prashant
Otto, Mario
author_sort Sharma, Prashant
collection PubMed
description Cancer immunotherapy has gained momentum for treating malignant tumors over the past decade. Checkpoint blockade and chimeric antigen receptor cell therapy (CAR-T) have shown considerable potency against liquid and solid cancers. However, the tumor microenvironment (TME) is highly immunosuppressive and hampers the effect of currently available cancer immunotherapies on overall treatment outcomes. Advancements in the design and engineering of nanomaterials have opened new avenues to modulate the TME. Progress in the current nanocomposite technology can overcome immunosuppression and trigger robust immunotherapeutic responses by integrating synergistic functions of different molecules. We will review recent advancements in nanomedical applications and discuss specifically designed nanocomposites modulating the TME for cancer immunotherapy. In addition, we provide information on the current landscape of clinical-stage nanocomposites for cancer immunotherapy.
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spelling pubmed-104943222023-09-12 Multifunctional nanocomposites modulating the tumor microenvironment for enhanced cancer immunotherapy Sharma, Prashant Otto, Mario Bioact Mater Review Article Cancer immunotherapy has gained momentum for treating malignant tumors over the past decade. Checkpoint blockade and chimeric antigen receptor cell therapy (CAR-T) have shown considerable potency against liquid and solid cancers. However, the tumor microenvironment (TME) is highly immunosuppressive and hampers the effect of currently available cancer immunotherapies on overall treatment outcomes. Advancements in the design and engineering of nanomaterials have opened new avenues to modulate the TME. Progress in the current nanocomposite technology can overcome immunosuppression and trigger robust immunotherapeutic responses by integrating synergistic functions of different molecules. We will review recent advancements in nanomedical applications and discuss specifically designed nanocomposites modulating the TME for cancer immunotherapy. In addition, we provide information on the current landscape of clinical-stage nanocomposites for cancer immunotherapy. KeAi Publishing 2023-09-06 /pmc/articles/PMC10494322/ /pubmed/37701452 http://dx.doi.org/10.1016/j.bioactmat.2023.08.022 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Sharma, Prashant
Otto, Mario
Multifunctional nanocomposites modulating the tumor microenvironment for enhanced cancer immunotherapy
title Multifunctional nanocomposites modulating the tumor microenvironment for enhanced cancer immunotherapy
title_full Multifunctional nanocomposites modulating the tumor microenvironment for enhanced cancer immunotherapy
title_fullStr Multifunctional nanocomposites modulating the tumor microenvironment for enhanced cancer immunotherapy
title_full_unstemmed Multifunctional nanocomposites modulating the tumor microenvironment for enhanced cancer immunotherapy
title_short Multifunctional nanocomposites modulating the tumor microenvironment for enhanced cancer immunotherapy
title_sort multifunctional nanocomposites modulating the tumor microenvironment for enhanced cancer immunotherapy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494322/
https://www.ncbi.nlm.nih.gov/pubmed/37701452
http://dx.doi.org/10.1016/j.bioactmat.2023.08.022
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