Cargando…

Combination of RUNX1 inhibitor and gemcitabine mitigates chemo‐resistance in pancreatic ductal adenocarcinoma by modulating BiP/PERK/eIF2α-axis-mediated endoplasmic reticulum stress

BACKGROUND: Gemcitabine (GEM)-based chemotherapy is the first-line option for pancreatic ductal adenocarcinoma (PDAC). However, the development of drug resistance limits its efficacy, and the specific mechanisms remain largely unknown. RUNX1, a key transcription factor in hematopoiesis, also involve...

Descripción completa

Detalles Bibliográficos
Autores principales:	She, Chunhua, Wu, Chao, Guo, Weihua, Xie, Yongjie, Li, Shouyi, Liu, Weishuai, Xu, Chao, Li, Hui, Cao, Pei, Yang, Yanfang, Wang, Xiuchao, Chang, Antao, Feng, Yukuan, Hao, Jihui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494371/ https://www.ncbi.nlm.nih.gov/pubmed/37697370 http://dx.doi.org/10.1186/s13046-023-02814-x

Ejemplares similares

UPR proteins IRE1 and PERK switch BiP from chaperone to ER stress sensor
por: Kopp, Megan C, et al.
Publicado: (2019)

Nuclear PLD1 combined with NPM1 induces gemcitabine resistance through tumorigenic IL7R in pancreatic adenocarcinoma
por: Fu, Danqi, et al.
Publicado: (2023)

Nucleofection induces transient eIF2α phosphorylation by GCN2 and PERK
por: Anderson, Bart R., et al.
Publicado: (2012)

Avarol Induces Apoptosis in Pancreatic Ductal Adenocarcinoma Cells by Activating PERK–eIF2α–CHOP Signaling
por: Namba, Takushi, et al.
Publicado: (2015)

Regulation of PERK Signaling and Leukemic Cell Survival by a Novel Cytosolic Isoform of the UPR Regulator GRP78/BiP
por: Ni, Min, et al.
Publicado: (2009)

PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice
por: Iida, Kaori, et al.
Publicado: (2007)

Emerging Role for the PERK/eIF2α/ATF4 in Human Cutaneous Leishmaniasis
por: Dias-Teixeira, Karina Luiza, et al.
Publicado: (2017)

Activation of the PERK-ATF4 pathway promotes chemo-resistance in colon cancer cells
por: Shi, Zhong, et al.
Publicado: (2019)

Survival outcomes of neoadjuvant therapy followed by radical resection versus upfront surgery for stage I–III pancreatic ductal adenocarcinoma: a retrospective cohort study
por: Zou, Yiping, et al.
Publicado: (2023)

PERK (EIF2AK3) Regulates Proinsulin Trafficking and Quality Control in the Secretory Pathway
por: Gupta, Sounak, et al.
Publicado: (2010)

Neurodegeneration risk factor, EIF2AK3 (PERK), influences tau protein aggregation
por: Park, Goonho, et al.
Publicado: (2022)

Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein C(H)1 to initiate ER stress signaling
por: Carrara, Marta, et al.
Publicado: (2015)

Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma
por: Zhao, Tiansuo, et al.
Publicado: (2014)

Quzhi Formula Alleviates Nonalcoholic Steatohepatitis by Impairing Hepatocyte Lipid Accumulation and Inflammation via Bip/eIF2α Signaling
por: Wu, Yue-Lan, et al.
Publicado: (2022)

Correction: Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma
por: Zhao, Tiansuo, et al.
Publicado: (2019)

Irbesartan overcomes gemcitabine resistance in pancreatic cancer by suppressing stemness and iron metabolism via inhibition of the Hippo/YAP1/c-Jun axis
por: Zhou, Tianxing, et al.
Publicado: (2023)

Protein Tyrosine Phosphatase 1B Deficiency Potentiates PERK/eIF2α Signaling in Brown Adipocytes
por: Bettaieb, Ahmed, et al.
Publicado: (2012)

PERK‐eIF2α‐ATF4‐CHOP Signaling Contributes to TNFα‐Induced Vascular Calcification
por: Masuda, Masashi, et al.
Publicado: (2013)

Regulation of Autophagy Via PERK-eIF2α Effectively Relieve the Radiation Myelitis Induced by Iodine-125
por: Yang, Zuozhang, et al.
Publicado: (2013)

Effect of the Viral Hemorrhagic Septicemia Virus Nonvirion Protein on Translation via PERK-eIF2α Pathway
por: Kesterson, Shelby Powell, et al.
Publicado: (2020)

CPNE1 regulates myogenesis through the PERK-eIF2α pathway mediated by endoplasmic reticulum stress
por: Chen, Lin, et al.
Publicado: (2022)

Sinulariolide Induced Hepatocellular Carcinoma Apoptosis through Activation of Mitochondrial-Related Apoptotic and PERK/eIF2α/ATF4/CHOP Pathway
por: Chen, Yi-Jen, et al.
Publicado: (2013)

IL-37/ STAT3/ HIF-1α negative feedback signaling drives gemcitabine resistance in pancreatic cancer
por: Zhao, Tiansuo, et al.
Publicado: (2020)

The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress
por: Teske, Brian F., et al.
Publicado: (2011)

Modulation of the Akt Pathway Reveals a Novel Link with PERK/eIF2α, which Is Relevant during Hypoxia
por: Blaustein, Matías, et al.
Publicado: (2013)

Salubrinal protects against tunicamycin and hypoxia induced cardiomyocyte apoptosis via the PERK-eIF2α signaling pathway
por: Liu, Chun-Lei, et al.
Publicado: (2012)

The eIF2α kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression
por: Trinh, Mimi A., et al.
Publicado: (2014)

Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes
por: Jiang, Minqing, et al.
Publicado: (2016)

PERK-Mediated eIF2α Phosphorylation Contributes to The Protection of Dopaminergic Neurons from Chronic Heat Stress in Drosophila
por: Elvira, Rosalie, et al.
Publicado: (2020)

Salubrinal Regulates the Apoptosis of Adrenocortical Carcinoma Cells via the PERK/eIF2α/ATF4 Signaling Pathway
por: Wu, Lili, et al.
Publicado: (2021)

Cell-type-specific disruption of PERK-eIF2α signaling in dopaminergic neurons alters motor and cognitive function
por: Longo, Francesco, et al.
Publicado: (2021)

Ginsenoside Rb1 Ameliorated Bavachin-Induced Renal Fibrosis via Suppressing Bip/eIF2α/CHOP Signaling-Mediated EMT
por: Ni, Yu-Hao, et al.
Publicado: (2022)

CREBBP knockdown suppressed proliferation and promoted chemo-sensitivity via PERK-mediated unfolded protein response in ovarian cancer
por: Hu, Haoyang, et al.
Publicado: (2021)

Evidence for eIF2α phosphorylation-independent effects of GSK2656157, a novel catalytic inhibitor of PERK with clinical implications
por: Krishnamoorthy, Jothilatha, et al.
Publicado: (2014)

Corrigendum: Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes
por: Jiang, Minqing, et al.
Publicado: (2016)

IRE1α deficiency promotes tumor cell death and eIF2α degradation through PERK dipendent autophagy
por: Storniolo, Antonello, et al.
Publicado: (2018)

Endoplasmic reticulum stress pathway PERK‐eIF2α confers radioresistance in oropharyngeal carcinoma by activating NF‐κB
por: Qiao, Qiao, et al.
Publicado: (2017)

Role of the PERK-eIF2α-CHOP Signaling Pathway in the Effect of Needle Knife Therapy on Knee Joint Chondrocyte Apoptosis
por: Yang, Yong-hui, et al.
Publicado: (2019)

Hypoxia Induces Growth Differentiation Factor 15 to Promote the Metastasis of Colorectal Cancer via PERK-eIF2α Signaling
por: Zheng, Hongtu, et al.
Publicado: (2020)

Saturated Fatty Acids Promote GDF15 Expression in Human Macrophages through the PERK/eIF2/CHOP Signaling Pathway
por: L’homme, Laurent, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_8er17co21lmdcrim9q4o1a5rhf