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Association between inpatient glycemic variability and COVID-19 mortality: a prospective study

BACKGROUND: This study aimed to determine the association between glycemic variability (GV) and mortality in hospitalized patients with coronavirus disease 2019 (COVID-19). METHODS: We prospectively analyzed data from inpatients (> 18 years old) with RT-PCR confirmed COVID-19 admitted between Mar...

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Autores principales: Ali El Chab Parolin, Salma, Benicio Stocco, Rebecca, Kneipp Lopes, Julia do Carmo, Curcio Pereira, Marcos Roberto, Massae Yamashita, Milena, Domareski Goulart, Maria Eduarda, Demeneck, Henrique, Olandoski, Marcia, Hermann de Souza Nunes, Larissa, Keniche Morisawa, Victor, Fanhani Cracco, Luiz Augusto, Busto Silva, Isabela, Silva Motta Júnior, Jarbas, Veit Barreto, Daniela, Lenci Marques, Gustavo, Proença de Moraes, Thyago, Pellegrino Baena, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494398/
https://www.ncbi.nlm.nih.gov/pubmed/37697407
http://dx.doi.org/10.1186/s13098-023-01157-z
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author Ali El Chab Parolin, Salma
Benicio Stocco, Rebecca
Kneipp Lopes, Julia do Carmo
Curcio Pereira, Marcos Roberto
Massae Yamashita, Milena
Domareski Goulart, Maria Eduarda
Demeneck, Henrique
Olandoski, Marcia
Hermann de Souza Nunes, Larissa
Keniche Morisawa, Victor
Fanhani Cracco, Luiz Augusto
Busto Silva, Isabela
Silva Motta Júnior, Jarbas
Veit Barreto, Daniela
Lenci Marques, Gustavo
Proença de Moraes, Thyago
Pellegrino Baena, Cristina
author_facet Ali El Chab Parolin, Salma
Benicio Stocco, Rebecca
Kneipp Lopes, Julia do Carmo
Curcio Pereira, Marcos Roberto
Massae Yamashita, Milena
Domareski Goulart, Maria Eduarda
Demeneck, Henrique
Olandoski, Marcia
Hermann de Souza Nunes, Larissa
Keniche Morisawa, Victor
Fanhani Cracco, Luiz Augusto
Busto Silva, Isabela
Silva Motta Júnior, Jarbas
Veit Barreto, Daniela
Lenci Marques, Gustavo
Proença de Moraes, Thyago
Pellegrino Baena, Cristina
author_sort Ali El Chab Parolin, Salma
collection PubMed
description BACKGROUND: This study aimed to determine the association between glycemic variability (GV) and mortality in hospitalized patients with coronavirus disease 2019 (COVID-19). METHODS: We prospectively analyzed data from inpatients (> 18 years old) with RT-PCR confirmed COVID-19 admitted between March 2020 and July 2021. All patients were hospitalized for more than 48 h and had at least six point-of-care capillary glucose tests obtained three times daily in the pre-prandial period during hospitalization. GV was measured using the glucose standard deviation (SD) and coefficient of variation (CV). ROC curve was adjusted to determine the SD and CV cutoff values associated with mortality (44.7 mg/dL and 27.5%, respectively); values above these were considered indicative of high GV. Logistic regression models were fitted to explore the association between GV and mortality in patients with and without diabetes. RESULTS: A total of 628 patients were stratified into SD < 44.7 mg/dL (n = 357) versus ≥ 44.7 mg/dL (n = 271) and CV < 27.5% (n = 318) versus ≥ 27.5% (n = 310) groups. After controlling for age, sex, presence of diabetes mellitus (DM) and cardiovascular disease, we found a significant association between high GV and mortality (odds ratio 2.99 [1.88–4.77] for SD and 2.43 [1.54–3.85] for CV; p values < 0.001). The mortality rate was higher with SD ≥ 44.7 mg/dL and CV ≥ 27.5% compared to that with SD < 44.7 mg/dL and CV < 27.5%, regardless of DM (p < 0.001 for all). CONCLUSION: High glycemic variability was independently associated with mortality in patients with and without DM, who were hospitalized with COVID-19.
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spelling pubmed-104943982023-09-12 Association between inpatient glycemic variability and COVID-19 mortality: a prospective study Ali El Chab Parolin, Salma Benicio Stocco, Rebecca Kneipp Lopes, Julia do Carmo Curcio Pereira, Marcos Roberto Massae Yamashita, Milena Domareski Goulart, Maria Eduarda Demeneck, Henrique Olandoski, Marcia Hermann de Souza Nunes, Larissa Keniche Morisawa, Victor Fanhani Cracco, Luiz Augusto Busto Silva, Isabela Silva Motta Júnior, Jarbas Veit Barreto, Daniela Lenci Marques, Gustavo Proença de Moraes, Thyago Pellegrino Baena, Cristina Diabetol Metab Syndr Research BACKGROUND: This study aimed to determine the association between glycemic variability (GV) and mortality in hospitalized patients with coronavirus disease 2019 (COVID-19). METHODS: We prospectively analyzed data from inpatients (> 18 years old) with RT-PCR confirmed COVID-19 admitted between March 2020 and July 2021. All patients were hospitalized for more than 48 h and had at least six point-of-care capillary glucose tests obtained three times daily in the pre-prandial period during hospitalization. GV was measured using the glucose standard deviation (SD) and coefficient of variation (CV). ROC curve was adjusted to determine the SD and CV cutoff values associated with mortality (44.7 mg/dL and 27.5%, respectively); values above these were considered indicative of high GV. Logistic regression models were fitted to explore the association between GV and mortality in patients with and without diabetes. RESULTS: A total of 628 patients were stratified into SD < 44.7 mg/dL (n = 357) versus ≥ 44.7 mg/dL (n = 271) and CV < 27.5% (n = 318) versus ≥ 27.5% (n = 310) groups. After controlling for age, sex, presence of diabetes mellitus (DM) and cardiovascular disease, we found a significant association between high GV and mortality (odds ratio 2.99 [1.88–4.77] for SD and 2.43 [1.54–3.85] for CV; p values < 0.001). The mortality rate was higher with SD ≥ 44.7 mg/dL and CV ≥ 27.5% compared to that with SD < 44.7 mg/dL and CV < 27.5%, regardless of DM (p < 0.001 for all). CONCLUSION: High glycemic variability was independently associated with mortality in patients with and without DM, who were hospitalized with COVID-19. BioMed Central 2023-09-11 /pmc/articles/PMC10494398/ /pubmed/37697407 http://dx.doi.org/10.1186/s13098-023-01157-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Ali El Chab Parolin, Salma
Benicio Stocco, Rebecca
Kneipp Lopes, Julia do Carmo
Curcio Pereira, Marcos Roberto
Massae Yamashita, Milena
Domareski Goulart, Maria Eduarda
Demeneck, Henrique
Olandoski, Marcia
Hermann de Souza Nunes, Larissa
Keniche Morisawa, Victor
Fanhani Cracco, Luiz Augusto
Busto Silva, Isabela
Silva Motta Júnior, Jarbas
Veit Barreto, Daniela
Lenci Marques, Gustavo
Proença de Moraes, Thyago
Pellegrino Baena, Cristina
Association between inpatient glycemic variability and COVID-19 mortality: a prospective study
title Association between inpatient glycemic variability and COVID-19 mortality: a prospective study
title_full Association between inpatient glycemic variability and COVID-19 mortality: a prospective study
title_fullStr Association between inpatient glycemic variability and COVID-19 mortality: a prospective study
title_full_unstemmed Association between inpatient glycemic variability and COVID-19 mortality: a prospective study
title_short Association between inpatient glycemic variability and COVID-19 mortality: a prospective study
title_sort association between inpatient glycemic variability and covid-19 mortality: a prospective study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494398/
https://www.ncbi.nlm.nih.gov/pubmed/37697407
http://dx.doi.org/10.1186/s13098-023-01157-z
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