Sustained induction of IP-10 by MRP8/14 via the IFNβ–IRF7 axis in macrophages exaggerates lung injury in endotoxemic mice

BACKGROUND: As a damage-associated molecular pattern, the myeloid-related protein 8/14 (MRP8/14) heterodimer mediates various inflammatory diseases, such as sepsis. However, how MRP8/14 promotes lung injury by regulating the inflammatory response during endotoxemia remains largely unknown. This stud...

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Detalles Bibliográficos
Autores principales: Wang, Juan, Chen, Guiming, Li, Lei, Luo, Sidan, Hu, Bingrong, Xu, Jia, Luo, Haihua, Li, Shan, Jiang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494486/
https://www.ncbi.nlm.nih.gov/pubmed/37701855
http://dx.doi.org/10.1093/burnst/tkad006

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