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The factors predicting development of serious infections in ANCA-associated vasculitis
BACKGROUND: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare autoimmune disease usually involving small vessels and progressing with necrotizing inflammation. Treatment requires long-term use of immunosuppressive agents to inhibit disease activity. Serious infections...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mattioli 1885
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494754/ https://www.ncbi.nlm.nih.gov/pubmed/37382076 http://dx.doi.org/10.36141/svdld.v40i2.13243 |
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author | Uslu Yurteri, Emine Sezer, Serdar Torgutalp, Murat Yayla, Müçteba Enes Sahin Eroglu, Didem Okatan, Ilyas Ercan Keleşoğlu Dinçer, Ayşe Bahar Aydemir Gülöksüz, Emine Gözde Yüksel, Mehmet Levent Turgay, Tahsin Murat Ateş, Aşkın Kınıklı, Gülay |
author_facet | Uslu Yurteri, Emine Sezer, Serdar Torgutalp, Murat Yayla, Müçteba Enes Sahin Eroglu, Didem Okatan, Ilyas Ercan Keleşoğlu Dinçer, Ayşe Bahar Aydemir Gülöksüz, Emine Gözde Yüksel, Mehmet Levent Turgay, Tahsin Murat Ateş, Aşkın Kınıklı, Gülay |
author_sort | Uslu Yurteri, Emine |
collection | PubMed |
description | BACKGROUND: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare autoimmune disease usually involving small vessels and progressing with necrotizing inflammation. Treatment requires long-term use of immunosuppressive agents to inhibit disease activity. Serious infections (SIs) are a common complication in AAV. OBJECTIVE: The aim of this study was to identify the risk factors for serious infections which required hospitalization in patients with AAV. METHODS: In this retrospective cohort study., we included 84 patients admitted to the Ankara University Faculty of Medicine in the last 10 years with a diagnosis of AAV. RESULTS: In 42 (50%) of 84 patients followed up with the diagnosis of AAV, an infection requiring hospitalization was identified. The patients’ total corticosteroid dose, use of pulse steroids, induction regimen, levels of C-reactive protein (CRP) and the presence of pulmonary and renopulmonary involvement were found to be associated with the frequency of infection (p=0.015, p=0.016, p=0.010, p=0.03, p= 0.026 and p=0.029, respectively). In multivariable analysis, it was found that renopulmonary involvement (p=0.002, HR=4.95, 95% CI= 1.804-13.605), age of over 65 (p=0.049, HR=3.37, 95% CI=1.004-11.369) and high CRP levels (p=0.043, HR=1.006, 95% CI=1.000-1.011) constituted independent predictors of serious infection risk. CONCLUSION: The frequency of infection is known to be increased in ANCA-associated vasculitis. Our study showed that renopulmonary involvement, age and elevated CRP levels on admission are independent risk factors of infection. |
format | Online Article Text |
id | pubmed-10494754 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Mattioli 1885 |
record_format | MEDLINE/PubMed |
spelling | pubmed-104947542023-09-12 The factors predicting development of serious infections in ANCA-associated vasculitis Uslu Yurteri, Emine Sezer, Serdar Torgutalp, Murat Yayla, Müçteba Enes Sahin Eroglu, Didem Okatan, Ilyas Ercan Keleşoğlu Dinçer, Ayşe Bahar Aydemir Gülöksüz, Emine Gözde Yüksel, Mehmet Levent Turgay, Tahsin Murat Ateş, Aşkın Kınıklı, Gülay Sarcoidosis Vasc Diffuse Lung Dis Original Article: Laboratory Research BACKGROUND: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare autoimmune disease usually involving small vessels and progressing with necrotizing inflammation. Treatment requires long-term use of immunosuppressive agents to inhibit disease activity. Serious infections (SIs) are a common complication in AAV. OBJECTIVE: The aim of this study was to identify the risk factors for serious infections which required hospitalization in patients with AAV. METHODS: In this retrospective cohort study., we included 84 patients admitted to the Ankara University Faculty of Medicine in the last 10 years with a diagnosis of AAV. RESULTS: In 42 (50%) of 84 patients followed up with the diagnosis of AAV, an infection requiring hospitalization was identified. The patients’ total corticosteroid dose, use of pulse steroids, induction regimen, levels of C-reactive protein (CRP) and the presence of pulmonary and renopulmonary involvement were found to be associated with the frequency of infection (p=0.015, p=0.016, p=0.010, p=0.03, p= 0.026 and p=0.029, respectively). In multivariable analysis, it was found that renopulmonary involvement (p=0.002, HR=4.95, 95% CI= 1.804-13.605), age of over 65 (p=0.049, HR=3.37, 95% CI=1.004-11.369) and high CRP levels (p=0.043, HR=1.006, 95% CI=1.000-1.011) constituted independent predictors of serious infection risk. CONCLUSION: The frequency of infection is known to be increased in ANCA-associated vasculitis. Our study showed that renopulmonary involvement, age and elevated CRP levels on admission are independent risk factors of infection. Mattioli 1885 2023 2023-06-29 /pmc/articles/PMC10494754/ /pubmed/37382076 http://dx.doi.org/10.36141/svdld.v40i2.13243 Text en Copyright: © 2023 SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES https://creativecommons.org/licenses/by-nc-sa/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License |
spellingShingle | Original Article: Laboratory Research Uslu Yurteri, Emine Sezer, Serdar Torgutalp, Murat Yayla, Müçteba Enes Sahin Eroglu, Didem Okatan, Ilyas Ercan Keleşoğlu Dinçer, Ayşe Bahar Aydemir Gülöksüz, Emine Gözde Yüksel, Mehmet Levent Turgay, Tahsin Murat Ateş, Aşkın Kınıklı, Gülay The factors predicting development of serious infections in ANCA-associated vasculitis |
title | The factors predicting development of serious infections in ANCA-associated vasculitis |
title_full | The factors predicting development of serious infections in ANCA-associated vasculitis |
title_fullStr | The factors predicting development of serious infections in ANCA-associated vasculitis |
title_full_unstemmed | The factors predicting development of serious infections in ANCA-associated vasculitis |
title_short | The factors predicting development of serious infections in ANCA-associated vasculitis |
title_sort | factors predicting development of serious infections in anca-associated vasculitis |
topic | Original Article: Laboratory Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494754/ https://www.ncbi.nlm.nih.gov/pubmed/37382076 http://dx.doi.org/10.36141/svdld.v40i2.13243 |
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