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Effectiveness of Catheter Ablation in Left Ventricular Ejection Fraction, Stroke, Quality of Life, All-Cause Mortality, Sinus Rhythm Maintenance, and Hospitalization Rates as Compared to Medical Therapy

Atrial fibrillation (AF) in the setting of heart failure (HF) accounts for a significant proportion of mortality. AF can be managed either with rate control or rhythm control strategies. Rate control involves the use of beta blockers or calcium channel blockers. Rhythm control methods use antiarrhyt...

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Autores principales: Oble, Mrinal J P, Sonia, Shamsun Nahar, George, Sherie, Shahi, Srushti R, Ali, Zahra, Abaza, Abdelrahman, Jamil, Aneeque, Gutlapalli, Sai Dheeraj, Ali, Marya, Mostafa, Jihan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494759/
https://www.ncbi.nlm.nih.gov/pubmed/37700942
http://dx.doi.org/10.7759/cureus.43372
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author Oble, Mrinal J P
Sonia, Shamsun Nahar
George, Sherie
Shahi, Srushti R
Ali, Zahra
Abaza, Abdelrahman
Jamil, Aneeque
Gutlapalli, Sai Dheeraj
Ali, Marya
Mostafa, Jihan
author_facet Oble, Mrinal J P
Sonia, Shamsun Nahar
George, Sherie
Shahi, Srushti R
Ali, Zahra
Abaza, Abdelrahman
Jamil, Aneeque
Gutlapalli, Sai Dheeraj
Ali, Marya
Mostafa, Jihan
author_sort Oble, Mrinal J P
collection PubMed
description Atrial fibrillation (AF) in the setting of heart failure (HF) accounts for a significant proportion of mortality. AF can be managed either with rate control or rhythm control strategies. Rate control involves the use of beta blockers or calcium channel blockers. Rhythm control methods use antiarrhythmic drugs or catheter ablation (CA) to abolish the rhythm. Articles from PubMed and Google Scholar were chosen for review. The literature was reviewed for data from the last 10 years to be chosen for interpretation. Clinical trials, meta-analyses, and systematic analysis were included in this study. Various health parameters such as all-cause mortality, hospitalization rates, sinus rhythm (SR) maintenance, quality of life improvement, stroke risk, left ventricular ejection fraction (LVEF) improvement, and healthcare costs were analyzed. We demonstrated that CA was superior to medical therapy in reducing all-cause mortality and hospitalization. It leads to significant improvement in LVEF as SR was maintained consistently. Overall, quality of life improved in those who underwent ablation as compared to those who did not. Stroke risk reduction was seen in observational studies only. We recommend CA as first-line therapy for treating patients with AF in the setting of HF. More clinical trials are needed to determine the effectiveness of ablation in reducing stroke risk.
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spelling pubmed-104947592023-09-12 Effectiveness of Catheter Ablation in Left Ventricular Ejection Fraction, Stroke, Quality of Life, All-Cause Mortality, Sinus Rhythm Maintenance, and Hospitalization Rates as Compared to Medical Therapy Oble, Mrinal J P Sonia, Shamsun Nahar George, Sherie Shahi, Srushti R Ali, Zahra Abaza, Abdelrahman Jamil, Aneeque Gutlapalli, Sai Dheeraj Ali, Marya Mostafa, Jihan Cureus Cardiology Atrial fibrillation (AF) in the setting of heart failure (HF) accounts for a significant proportion of mortality. AF can be managed either with rate control or rhythm control strategies. Rate control involves the use of beta blockers or calcium channel blockers. Rhythm control methods use antiarrhythmic drugs or catheter ablation (CA) to abolish the rhythm. Articles from PubMed and Google Scholar were chosen for review. The literature was reviewed for data from the last 10 years to be chosen for interpretation. Clinical trials, meta-analyses, and systematic analysis were included in this study. Various health parameters such as all-cause mortality, hospitalization rates, sinus rhythm (SR) maintenance, quality of life improvement, stroke risk, left ventricular ejection fraction (LVEF) improvement, and healthcare costs were analyzed. We demonstrated that CA was superior to medical therapy in reducing all-cause mortality and hospitalization. It leads to significant improvement in LVEF as SR was maintained consistently. Overall, quality of life improved in those who underwent ablation as compared to those who did not. Stroke risk reduction was seen in observational studies only. We recommend CA as first-line therapy for treating patients with AF in the setting of HF. More clinical trials are needed to determine the effectiveness of ablation in reducing stroke risk. Cureus 2023-08-12 /pmc/articles/PMC10494759/ /pubmed/37700942 http://dx.doi.org/10.7759/cureus.43372 Text en Copyright © 2023, Oble et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Oble, Mrinal J P
Sonia, Shamsun Nahar
George, Sherie
Shahi, Srushti R
Ali, Zahra
Abaza, Abdelrahman
Jamil, Aneeque
Gutlapalli, Sai Dheeraj
Ali, Marya
Mostafa, Jihan
Effectiveness of Catheter Ablation in Left Ventricular Ejection Fraction, Stroke, Quality of Life, All-Cause Mortality, Sinus Rhythm Maintenance, and Hospitalization Rates as Compared to Medical Therapy
title Effectiveness of Catheter Ablation in Left Ventricular Ejection Fraction, Stroke, Quality of Life, All-Cause Mortality, Sinus Rhythm Maintenance, and Hospitalization Rates as Compared to Medical Therapy
title_full Effectiveness of Catheter Ablation in Left Ventricular Ejection Fraction, Stroke, Quality of Life, All-Cause Mortality, Sinus Rhythm Maintenance, and Hospitalization Rates as Compared to Medical Therapy
title_fullStr Effectiveness of Catheter Ablation in Left Ventricular Ejection Fraction, Stroke, Quality of Life, All-Cause Mortality, Sinus Rhythm Maintenance, and Hospitalization Rates as Compared to Medical Therapy
title_full_unstemmed Effectiveness of Catheter Ablation in Left Ventricular Ejection Fraction, Stroke, Quality of Life, All-Cause Mortality, Sinus Rhythm Maintenance, and Hospitalization Rates as Compared to Medical Therapy
title_short Effectiveness of Catheter Ablation in Left Ventricular Ejection Fraction, Stroke, Quality of Life, All-Cause Mortality, Sinus Rhythm Maintenance, and Hospitalization Rates as Compared to Medical Therapy
title_sort effectiveness of catheter ablation in left ventricular ejection fraction, stroke, quality of life, all-cause mortality, sinus rhythm maintenance, and hospitalization rates as compared to medical therapy
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494759/
https://www.ncbi.nlm.nih.gov/pubmed/37700942
http://dx.doi.org/10.7759/cureus.43372
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