Cargando…

Prognostic value of a decrease in mean platelet volume, platelet distribution width, and platelet-large cell ratio for major adverse cardiovascular events after myocardial infarction without ST-segment elevation: An observational study

The current study aimed to explore whether the level of decrease in platelet distribution width (PDW), platelet-large cell ratio (P-LCR), and mean platelet volume (MPV) has prognostic value for major adverse cardiovascular events (MACEs) in acute myocardial infarction without ST-segment elevation (N...

Descripción completa

Detalles Bibliográficos
Autores principales: Bećirović, Emir, Ljuca, Kenana, Bećirović, Minela, Ljuca, Nadina, Bajrić, Mugdim, Brkić, Ammar, Ljuca, Farid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494847/
https://www.ncbi.nlm.nih.gov/pubmed/37212038
http://dx.doi.org/10.17305/bb.2023.9178
_version_ 1785104785586782208
author Bećirović, Emir
Ljuca, Kenana
Bećirović, Minela
Ljuca, Nadina
Bajrić, Mugdim
Brkić, Ammar
Ljuca, Farid
author_facet Bećirović, Emir
Ljuca, Kenana
Bećirović, Minela
Ljuca, Nadina
Bajrić, Mugdim
Brkić, Ammar
Ljuca, Farid
author_sort Bećirović, Emir
collection PubMed
description The current study aimed to explore whether the level of decrease in platelet distribution width (PDW), platelet-large cell ratio (P-LCR), and mean platelet volume (MPV) has prognostic value for major adverse cardiovascular events (MACEs) in acute myocardial infarction without ST-segment elevation (NSTEMI) treated with clopidogrel. In this prospective observational cohort study, PDW, P-LCR, and MPV were determined on admission at the hospital and 24 h after clopidogrel treatment in 170 non-STEMI patients. MACEs were assessed over a one-year follow-up period. Using the Cox regression test, a decrease in PDW showed a significant association with the incidence of MACEs (odds ratio [OR] 0.82, 95% confidence interval [CI] 0.66–0.99, p ═ 0.049) and overall survival rate (OR 0.95, 95% CI ═ 0.91–0.99, p ═ 0.016). Patients with a decrease in PDW<9.9% had a higher incidence of MACEs (OR 0.42, 95% CI ═ 0.24–0.72, p ═ 0.002) and a lower survival rate (OR 0.32, 95% CI ═ 0.12–0.90, p ═ 0.03) than patients who had a decrease in PDW<9.9%. In the Kaplan–Meier analysis using log-rank test, patients who had a decrease in PDW<9.9% had an increased risk for MACEs (p ═ 0.002) and lethal outcomes (p ═ 0.002). However, a decrease in MPV or P-LCR did not have prognostic value. A decrease in PDW<9.9% measured 24 h after clopidogrel treatment in NSTEMI patients has good prognostic value for determining the short-term risks of MACEs, possibly providing a better risk stratification of those patients.
format Online
Article
Text
id pubmed-10494847
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
record_format MEDLINE/PubMed
spelling pubmed-104948472023-10-01 Prognostic value of a decrease in mean platelet volume, platelet distribution width, and platelet-large cell ratio for major adverse cardiovascular events after myocardial infarction without ST-segment elevation: An observational study Bećirović, Emir Ljuca, Kenana Bećirović, Minela Ljuca, Nadina Bajrić, Mugdim Brkić, Ammar Ljuca, Farid Biomol Biomed Research Article The current study aimed to explore whether the level of decrease in platelet distribution width (PDW), platelet-large cell ratio (P-LCR), and mean platelet volume (MPV) has prognostic value for major adverse cardiovascular events (MACEs) in acute myocardial infarction without ST-segment elevation (NSTEMI) treated with clopidogrel. In this prospective observational cohort study, PDW, P-LCR, and MPV were determined on admission at the hospital and 24 h after clopidogrel treatment in 170 non-STEMI patients. MACEs were assessed over a one-year follow-up period. Using the Cox regression test, a decrease in PDW showed a significant association with the incidence of MACEs (odds ratio [OR] 0.82, 95% confidence interval [CI] 0.66–0.99, p ═ 0.049) and overall survival rate (OR 0.95, 95% CI ═ 0.91–0.99, p ═ 0.016). Patients with a decrease in PDW<9.9% had a higher incidence of MACEs (OR 0.42, 95% CI ═ 0.24–0.72, p ═ 0.002) and a lower survival rate (OR 0.32, 95% CI ═ 0.12–0.90, p ═ 0.03) than patients who had a decrease in PDW<9.9%. In the Kaplan–Meier analysis using log-rank test, patients who had a decrease in PDW<9.9% had an increased risk for MACEs (p ═ 0.002) and lethal outcomes (p ═ 0.002). However, a decrease in MPV or P-LCR did not have prognostic value. A decrease in PDW<9.9% measured 24 h after clopidogrel treatment in NSTEMI patients has good prognostic value for determining the short-term risks of MACEs, possibly providing a better risk stratification of those patients. Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2023-10-01 2023-10-01 /pmc/articles/PMC10494847/ /pubmed/37212038 http://dx.doi.org/10.17305/bb.2023.9178 Text en © 2023 Bećirović et al. https://creativecommons.org/licenses/by/4.0/This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).
spellingShingle Research Article
Bećirović, Emir
Ljuca, Kenana
Bećirović, Minela
Ljuca, Nadina
Bajrić, Mugdim
Brkić, Ammar
Ljuca, Farid
Prognostic value of a decrease in mean platelet volume, platelet distribution width, and platelet-large cell ratio for major adverse cardiovascular events after myocardial infarction without ST-segment elevation: An observational study
title Prognostic value of a decrease in mean platelet volume, platelet distribution width, and platelet-large cell ratio for major adverse cardiovascular events after myocardial infarction without ST-segment elevation: An observational study
title_full Prognostic value of a decrease in mean platelet volume, platelet distribution width, and platelet-large cell ratio for major adverse cardiovascular events after myocardial infarction without ST-segment elevation: An observational study
title_fullStr Prognostic value of a decrease in mean platelet volume, platelet distribution width, and platelet-large cell ratio for major adverse cardiovascular events after myocardial infarction without ST-segment elevation: An observational study
title_full_unstemmed Prognostic value of a decrease in mean platelet volume, platelet distribution width, and platelet-large cell ratio for major adverse cardiovascular events after myocardial infarction without ST-segment elevation: An observational study
title_short Prognostic value of a decrease in mean platelet volume, platelet distribution width, and platelet-large cell ratio for major adverse cardiovascular events after myocardial infarction without ST-segment elevation: An observational study
title_sort prognostic value of a decrease in mean platelet volume, platelet distribution width, and platelet-large cell ratio for major adverse cardiovascular events after myocardial infarction without st-segment elevation: an observational study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494847/
https://www.ncbi.nlm.nih.gov/pubmed/37212038
http://dx.doi.org/10.17305/bb.2023.9178
work_keys_str_mv AT becirovicemir prognosticvalueofadecreaseinmeanplateletvolumeplateletdistributionwidthandplateletlargecellratioformajoradversecardiovasculareventsaftermyocardialinfarctionwithoutstsegmentelevationanobservationalstudy
AT ljucakenana prognosticvalueofadecreaseinmeanplateletvolumeplateletdistributionwidthandplateletlargecellratioformajoradversecardiovasculareventsaftermyocardialinfarctionwithoutstsegmentelevationanobservationalstudy
AT becirovicminela prognosticvalueofadecreaseinmeanplateletvolumeplateletdistributionwidthandplateletlargecellratioformajoradversecardiovasculareventsaftermyocardialinfarctionwithoutstsegmentelevationanobservationalstudy
AT ljucanadina prognosticvalueofadecreaseinmeanplateletvolumeplateletdistributionwidthandplateletlargecellratioformajoradversecardiovasculareventsaftermyocardialinfarctionwithoutstsegmentelevationanobservationalstudy
AT bajricmugdim prognosticvalueofadecreaseinmeanplateletvolumeplateletdistributionwidthandplateletlargecellratioformajoradversecardiovasculareventsaftermyocardialinfarctionwithoutstsegmentelevationanobservationalstudy
AT brkicammar prognosticvalueofadecreaseinmeanplateletvolumeplateletdistributionwidthandplateletlargecellratioformajoradversecardiovasculareventsaftermyocardialinfarctionwithoutstsegmentelevationanobservationalstudy
AT ljucafarid prognosticvalueofadecreaseinmeanplateletvolumeplateletdistributionwidthandplateletlargecellratioformajoradversecardiovasculareventsaftermyocardialinfarctionwithoutstsegmentelevationanobservationalstudy