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Validation of Doi’s weighted average glucose as a measure of post-load glucose excursion for clinical use

In this study, we examined the performance of a novel index of glucose excursion (Doi’s weighted average glucose [dwAG]) in relation to the conventional measure of area under the oral glucose tolerance test (A-GTT) and the homeostatic model assessment for insulin sensitivity (HOMA-S) and pancreatic...

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Autores principales: Badran, Saif, Doi, Suhail A, Hammouda, Atalla, Musa, Omran A H, Habib, Abdella M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494857/
https://www.ncbi.nlm.nih.gov/pubmed/36967663
http://dx.doi.org/10.17305/bb.2022.8807
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author Badran, Saif
Doi, Suhail A
Hammouda, Atalla
Musa, Omran A H
Habib, Abdella M
author_facet Badran, Saif
Doi, Suhail A
Hammouda, Atalla
Musa, Omran A H
Habib, Abdella M
author_sort Badran, Saif
collection PubMed
description In this study, we examined the performance of a novel index of glucose excursion (Doi’s weighted average glucose [dwAG]) in relation to the conventional measure of area under the oral glucose tolerance test (A-GTT) and the homeostatic model assessment for insulin sensitivity (HOMA-S) and pancreatic beta cell function (HOMA-B). A cross-sectional comparison of the new index was conducted using 66 oral glucose tolerance tests (GTTs) performed at different follow-up times among 27 participants who had undergone surgical subcutaneous fat removal (SSFR). Comparisons across categories were made using box plots and the Kruskal–Wallis one-way ANOVA on ranks. Passing-Bablok regression was used to compare the dwAG against the conventional A-GTT. The Passing-Bablok regression model suggested a cutoff for normality for the A-GTT of 15.14 mmol/L⋅2h(−1) compared to the dwAG’s suggested threshold of 6.8 mmol/L. For every 1 mmol/L⋅2h(−1) increase in A-GTT, the dwAG value increased by 0.473 mmol/L. The glucose area under the curve correlated well with the four defined dwAG categories, with at least one of the categories having a different median A-GTT value (KW Chi2 ═ 52.8 [df ═ 3], P < 0.001). The HOMA-S tertiles were also associated with significantly different levels of glucose excursion measured through both the dwAG value (KW Chi2 ═ 11.4 [df ═ 2], P ═ 0.003) and A-GTT measure (KW Chi2 ═ 13.1 [df ═ 2], P ═ 0.001). It is concluded that the dwAG value and categories serve as a simple and accurate tool that can be used for interpreting glucose homeostasis across clinical settings.
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spelling pubmed-104948572023-10-01 Validation of Doi’s weighted average glucose as a measure of post-load glucose excursion for clinical use Badran, Saif Doi, Suhail A Hammouda, Atalla Musa, Omran A H Habib, Abdella M Biomol Biomed Research Article In this study, we examined the performance of a novel index of glucose excursion (Doi’s weighted average glucose [dwAG]) in relation to the conventional measure of area under the oral glucose tolerance test (A-GTT) and the homeostatic model assessment for insulin sensitivity (HOMA-S) and pancreatic beta cell function (HOMA-B). A cross-sectional comparison of the new index was conducted using 66 oral glucose tolerance tests (GTTs) performed at different follow-up times among 27 participants who had undergone surgical subcutaneous fat removal (SSFR). Comparisons across categories were made using box plots and the Kruskal–Wallis one-way ANOVA on ranks. Passing-Bablok regression was used to compare the dwAG against the conventional A-GTT. The Passing-Bablok regression model suggested a cutoff for normality for the A-GTT of 15.14 mmol/L⋅2h(−1) compared to the dwAG’s suggested threshold of 6.8 mmol/L. For every 1 mmol/L⋅2h(−1) increase in A-GTT, the dwAG value increased by 0.473 mmol/L. The glucose area under the curve correlated well with the four defined dwAG categories, with at least one of the categories having a different median A-GTT value (KW Chi2 ═ 52.8 [df ═ 3], P < 0.001). The HOMA-S tertiles were also associated with significantly different levels of glucose excursion measured through both the dwAG value (KW Chi2 ═ 11.4 [df ═ 2], P ═ 0.003) and A-GTT measure (KW Chi2 ═ 13.1 [df ═ 2], P ═ 0.001). It is concluded that the dwAG value and categories serve as a simple and accurate tool that can be used for interpreting glucose homeostasis across clinical settings. Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2023-10-01 2023-10-01 /pmc/articles/PMC10494857/ /pubmed/36967663 http://dx.doi.org/10.17305/bb.2022.8807 Text en © 2023 Badran et al. https://creativecommons.org/licenses/by/4.0/This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).
spellingShingle Research Article
Badran, Saif
Doi, Suhail A
Hammouda, Atalla
Musa, Omran A H
Habib, Abdella M
Validation of Doi’s weighted average glucose as a measure of post-load glucose excursion for clinical use
title Validation of Doi’s weighted average glucose as a measure of post-load glucose excursion for clinical use
title_full Validation of Doi’s weighted average glucose as a measure of post-load glucose excursion for clinical use
title_fullStr Validation of Doi’s weighted average glucose as a measure of post-load glucose excursion for clinical use
title_full_unstemmed Validation of Doi’s weighted average glucose as a measure of post-load glucose excursion for clinical use
title_short Validation of Doi’s weighted average glucose as a measure of post-load glucose excursion for clinical use
title_sort validation of doi’s weighted average glucose as a measure of post-load glucose excursion for clinical use
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494857/
https://www.ncbi.nlm.nih.gov/pubmed/36967663
http://dx.doi.org/10.17305/bb.2022.8807
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