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Effect of Hypoglycemic Drugs on Kisspeptin Expression in the Hypothalamic Arcuate Nucleus of PCOS Rats
BACKGROUND: To investigate the change in hypothalamic kisspeptin-1 (Kiss1) expression during the development of polycystic ovary syndrome (PCOS) and hypoglycemic drug intervention. METHODS: Letrozole lavage was used to construct a polycystic ovary rat model. After successful modeling, we treated PCO...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494929/ https://www.ncbi.nlm.nih.gov/pubmed/37701721 http://dx.doi.org/10.2147/DMSO.S421911 |
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author | Zheng, Pingping Lu, Yating Tang, You Xu, Fudong Wang, Lin Qian, Rui Hui, Cancan Xu, Qian He, Jianle Deng, Datong |
author_facet | Zheng, Pingping Lu, Yating Tang, You Xu, Fudong Wang, Lin Qian, Rui Hui, Cancan Xu, Qian He, Jianle Deng, Datong |
author_sort | Zheng, Pingping |
collection | PubMed |
description | BACKGROUND: To investigate the change in hypothalamic kisspeptin-1 (Kiss1) expression during the development of polycystic ovary syndrome (PCOS) and hypoglycemic drug intervention. METHODS: Letrozole lavage was used to construct a polycystic ovary rat model. After successful modeling, we treated PCOS rats with metformin, pioglitazone, and acarbose, and we then observed changes in weight, estrus, glucose tolerance, insulin resistance, sex hormones, and hypothalamic kiss1 expression. RESULTS: PCOS rats exhibited increased body weight, abnormal estrous cycle, impaired glucose tolerance, insulin resistance, increased testosterone level, increased luteinizing hormone level, and increased Kiss1 expression in the hypothalamus. However, intervention with metformin, pioglitazone, and acarbose improved the reproductive and metabolic disorders as well as reduced hypothalamic Kiss1 expression. CONCLUSION: The expression of hypothalamic Kiss1 may play an important role in the pathogenesis of PCOS. Metformin, pioglitazone, and acarbose may reduce the expression of hypothalamic Kiss1 by improving insulin resistance, thereby improving reproductive and metabolic disorders in PCOS rats. |
format | Online Article Text |
id | pubmed-10494929 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-104949292023-09-12 Effect of Hypoglycemic Drugs on Kisspeptin Expression in the Hypothalamic Arcuate Nucleus of PCOS Rats Zheng, Pingping Lu, Yating Tang, You Xu, Fudong Wang, Lin Qian, Rui Hui, Cancan Xu, Qian He, Jianle Deng, Datong Diabetes Metab Syndr Obes Original Research BACKGROUND: To investigate the change in hypothalamic kisspeptin-1 (Kiss1) expression during the development of polycystic ovary syndrome (PCOS) and hypoglycemic drug intervention. METHODS: Letrozole lavage was used to construct a polycystic ovary rat model. After successful modeling, we treated PCOS rats with metformin, pioglitazone, and acarbose, and we then observed changes in weight, estrus, glucose tolerance, insulin resistance, sex hormones, and hypothalamic kiss1 expression. RESULTS: PCOS rats exhibited increased body weight, abnormal estrous cycle, impaired glucose tolerance, insulin resistance, increased testosterone level, increased luteinizing hormone level, and increased Kiss1 expression in the hypothalamus. However, intervention with metformin, pioglitazone, and acarbose improved the reproductive and metabolic disorders as well as reduced hypothalamic Kiss1 expression. CONCLUSION: The expression of hypothalamic Kiss1 may play an important role in the pathogenesis of PCOS. Metformin, pioglitazone, and acarbose may reduce the expression of hypothalamic Kiss1 by improving insulin resistance, thereby improving reproductive and metabolic disorders in PCOS rats. Dove 2023-09-07 /pmc/articles/PMC10494929/ /pubmed/37701721 http://dx.doi.org/10.2147/DMSO.S421911 Text en © 2023 Zheng et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Zheng, Pingping Lu, Yating Tang, You Xu, Fudong Wang, Lin Qian, Rui Hui, Cancan Xu, Qian He, Jianle Deng, Datong Effect of Hypoglycemic Drugs on Kisspeptin Expression in the Hypothalamic Arcuate Nucleus of PCOS Rats |
title | Effect of Hypoglycemic Drugs on Kisspeptin Expression in the Hypothalamic Arcuate Nucleus of PCOS Rats |
title_full | Effect of Hypoglycemic Drugs on Kisspeptin Expression in the Hypothalamic Arcuate Nucleus of PCOS Rats |
title_fullStr | Effect of Hypoglycemic Drugs on Kisspeptin Expression in the Hypothalamic Arcuate Nucleus of PCOS Rats |
title_full_unstemmed | Effect of Hypoglycemic Drugs on Kisspeptin Expression in the Hypothalamic Arcuate Nucleus of PCOS Rats |
title_short | Effect of Hypoglycemic Drugs on Kisspeptin Expression in the Hypothalamic Arcuate Nucleus of PCOS Rats |
title_sort | effect of hypoglycemic drugs on kisspeptin expression in the hypothalamic arcuate nucleus of pcos rats |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494929/ https://www.ncbi.nlm.nih.gov/pubmed/37701721 http://dx.doi.org/10.2147/DMSO.S421911 |
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