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Reading Vision in Adults With Early and Intermediate Age-Related Macular Degeneration Under Mesopic and Photopic Conditions

PURPOSE: Reading is involved in various daily activities that operate under a wide range of luminance levels. Rod- and cone-mediated mesopic visual function is known to be impaired even in early/intermediate age-related macular degeneration (AMD). It remains unclear whether and to what extent mesopi...

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Autores principales: Kwon, MiYoung, Owsley, Cynthia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494985/
https://www.ncbi.nlm.nih.gov/pubmed/37676678
http://dx.doi.org/10.1167/tvst.12.9.7
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author Kwon, MiYoung
Owsley, Cynthia
author_facet Kwon, MiYoung
Owsley, Cynthia
author_sort Kwon, MiYoung
collection PubMed
description PURPOSE: Reading is involved in various daily activities that operate under a wide range of luminance levels. Rod- and cone-mediated mesopic visual function is known to be impaired even in early/intermediate age-related macular degeneration (AMD). It remains unclear whether and to what extent mesopic reading is impaired in early/intermediate AMD. Here, we assessed differences in reading vision between photopic and mesopic conditions in early/intermediate AMD and compared their performance to those in older adults with normal macular health. METHODS: The study included 30 patients with early/intermediate AMD and 30 healthy controls. Reading performance was tested on the MNREAD iPad app under mesopic (2 cd/m(2) with a neural-density filter) and photopic (220 cd/m(2)) conditions. Four reading indices—maximum reading speed (MRS), critical print size (CPS), reading acuity (RA), and reading accessibility index (ACC)—were obtained from the MNREAD test, yielding a function representing reading speed versus print size. RESULTS: Compared to photopic conditions, patients with AMD and healthy controls both exhibited noticeable decreases in reading vision under mesopic conditions (P < 0.001) despite normal photopic visual acuity. This decrease was more pronounced in AMD even after adjusting for age (P < 0.001): Under mesopic conditions, MRS and ACC decreased by 8 words per minute and 0.1, respectively; CPS and RA were enlarged by 0.27 and 0.24 logMAR, respectively. CONCLUSIONS: Reading vision deteriorates under mesopic conditions compared to photopic conditions in early/intermediate AMD and is accentuated compared to this difference in healthy controls. TRANSLATIONAL RELEVANCE: A mesopic reading test may provide a more sensitive and comprehensive assessment of a patient's reading impairment.
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spelling pubmed-104949852023-09-12 Reading Vision in Adults With Early and Intermediate Age-Related Macular Degeneration Under Mesopic and Photopic Conditions Kwon, MiYoung Owsley, Cynthia Transl Vis Sci Technol Low Vision Rehabilitation PURPOSE: Reading is involved in various daily activities that operate under a wide range of luminance levels. Rod- and cone-mediated mesopic visual function is known to be impaired even in early/intermediate age-related macular degeneration (AMD). It remains unclear whether and to what extent mesopic reading is impaired in early/intermediate AMD. Here, we assessed differences in reading vision between photopic and mesopic conditions in early/intermediate AMD and compared their performance to those in older adults with normal macular health. METHODS: The study included 30 patients with early/intermediate AMD and 30 healthy controls. Reading performance was tested on the MNREAD iPad app under mesopic (2 cd/m(2) with a neural-density filter) and photopic (220 cd/m(2)) conditions. Four reading indices—maximum reading speed (MRS), critical print size (CPS), reading acuity (RA), and reading accessibility index (ACC)—were obtained from the MNREAD test, yielding a function representing reading speed versus print size. RESULTS: Compared to photopic conditions, patients with AMD and healthy controls both exhibited noticeable decreases in reading vision under mesopic conditions (P < 0.001) despite normal photopic visual acuity. This decrease was more pronounced in AMD even after adjusting for age (P < 0.001): Under mesopic conditions, MRS and ACC decreased by 8 words per minute and 0.1, respectively; CPS and RA were enlarged by 0.27 and 0.24 logMAR, respectively. CONCLUSIONS: Reading vision deteriorates under mesopic conditions compared to photopic conditions in early/intermediate AMD and is accentuated compared to this difference in healthy controls. TRANSLATIONAL RELEVANCE: A mesopic reading test may provide a more sensitive and comprehensive assessment of a patient's reading impairment. The Association for Research in Vision and Ophthalmology 2023-09-07 /pmc/articles/PMC10494985/ /pubmed/37676678 http://dx.doi.org/10.1167/tvst.12.9.7 Text en Copyright 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Low Vision Rehabilitation
Kwon, MiYoung
Owsley, Cynthia
Reading Vision in Adults With Early and Intermediate Age-Related Macular Degeneration Under Mesopic and Photopic Conditions
title Reading Vision in Adults With Early and Intermediate Age-Related Macular Degeneration Under Mesopic and Photopic Conditions
title_full Reading Vision in Adults With Early and Intermediate Age-Related Macular Degeneration Under Mesopic and Photopic Conditions
title_fullStr Reading Vision in Adults With Early and Intermediate Age-Related Macular Degeneration Under Mesopic and Photopic Conditions
title_full_unstemmed Reading Vision in Adults With Early and Intermediate Age-Related Macular Degeneration Under Mesopic and Photopic Conditions
title_short Reading Vision in Adults With Early and Intermediate Age-Related Macular Degeneration Under Mesopic and Photopic Conditions
title_sort reading vision in adults with early and intermediate age-related macular degeneration under mesopic and photopic conditions
topic Low Vision Rehabilitation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494985/
https://www.ncbi.nlm.nih.gov/pubmed/37676678
http://dx.doi.org/10.1167/tvst.12.9.7
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