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Anti Inflammatory Action of Allium Sativum Ethanol Extract to Prevent Lung Damage in Smoker Rat Model

BACKGROUND: Smoking is the leading cause of death in worldwide and is known as one of the risk factors in the development and pathogenesis of several diseases and most are respiratory and cardiovascular diseases. Secondhand smoke (SHS) exposure is associated with negative health consequences includi...

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Autores principales: Savira, Maya, Sari, Dina Keumala, Machrina, Yetty, Widjaja, Sry Suryani, Unitly, Adrien Jems Akiles, Ilyas, Syafruddin, Siregar, Jelita, Pandia, Pandiaman, Rusda, M., Amin, Mustafa M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academy of Medical Sciences of Bosnia and Herzegovina 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495143/
https://www.ncbi.nlm.nih.gov/pubmed/37700925
http://dx.doi.org/10.5455/medarh.2023.77.178-182
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author Savira, Maya
Sari, Dina Keumala
Machrina, Yetty
Widjaja, Sry Suryani
Unitly, Adrien Jems Akiles
Ilyas, Syafruddin
Siregar, Jelita
Pandia, Pandiaman
Rusda, M.
Amin, Mustafa M
author_facet Savira, Maya
Sari, Dina Keumala
Machrina, Yetty
Widjaja, Sry Suryani
Unitly, Adrien Jems Akiles
Ilyas, Syafruddin
Siregar, Jelita
Pandia, Pandiaman
Rusda, M.
Amin, Mustafa M
author_sort Savira, Maya
collection PubMed
description BACKGROUND: Smoking is the leading cause of death in worldwide and is known as one of the risk factors in the development and pathogenesis of several diseases and most are respiratory and cardiovascular diseases. Secondhand smoke (SHS) exposure is associated with negative health consequences including respiratory tract infection, asthma, and cancer. One of the pathogenesis that has known to cause these diseases is inflammation. Garlic (Allium sativum) is a medicinal herb that contains Allicin and other active constituents that are known to have anti-inflammatory ability by suppressing the expression and production of proinflammatory cytokines that will cause inflammation. OBJECTIVE: The aim of this study is; to analyze the anti-inflammatory action of Allium sativum ethanol extract to prevent lung damage in the smoker rat model. METHODS: This is a case-control study with five groups of rats each group contains of three rats. The five groups were negative control (KN), 10 days (10d) smoker (K1), 20 days (20d) smoker (K2), 20d smoker treated with Allium sativum for 10 days (K3) and 20d smoker treated with Allium sativum for 20 days (K4). After 20 days all animals were sacrificed and histological preparation of lung organs was observed under a microscope with 100 dan 400 times magnification and then captured by photomicrograph for analyzed. RESULTS: There were improvements in lung structure both in group K3 and K4 . there was a decrease of leucocytes and inflammatory cells infiltration that covered almost all alveolar surface to 10-20% surface area and the dilated alveoli decrease from more than 50% to less than 30% area. The bronchus was clean in both two groups compared to the groups that were not treated with Allium sativum CONCLUSION: This study shows that Allium sativum ethanol extract has the ability to prevent lung damage in the smoker rat model.
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spelling pubmed-104951432023-09-12 Anti Inflammatory Action of Allium Sativum Ethanol Extract to Prevent Lung Damage in Smoker Rat Model Savira, Maya Sari, Dina Keumala Machrina, Yetty Widjaja, Sry Suryani Unitly, Adrien Jems Akiles Ilyas, Syafruddin Siregar, Jelita Pandia, Pandiaman Rusda, M. Amin, Mustafa M Med Arch Original Paper BACKGROUND: Smoking is the leading cause of death in worldwide and is known as one of the risk factors in the development and pathogenesis of several diseases and most are respiratory and cardiovascular diseases. Secondhand smoke (SHS) exposure is associated with negative health consequences including respiratory tract infection, asthma, and cancer. One of the pathogenesis that has known to cause these diseases is inflammation. Garlic (Allium sativum) is a medicinal herb that contains Allicin and other active constituents that are known to have anti-inflammatory ability by suppressing the expression and production of proinflammatory cytokines that will cause inflammation. OBJECTIVE: The aim of this study is; to analyze the anti-inflammatory action of Allium sativum ethanol extract to prevent lung damage in the smoker rat model. METHODS: This is a case-control study with five groups of rats each group contains of three rats. The five groups were negative control (KN), 10 days (10d) smoker (K1), 20 days (20d) smoker (K2), 20d smoker treated with Allium sativum for 10 days (K3) and 20d smoker treated with Allium sativum for 20 days (K4). After 20 days all animals were sacrificed and histological preparation of lung organs was observed under a microscope with 100 dan 400 times magnification and then captured by photomicrograph for analyzed. RESULTS: There were improvements in lung structure both in group K3 and K4 . there was a decrease of leucocytes and inflammatory cells infiltration that covered almost all alveolar surface to 10-20% surface area and the dilated alveoli decrease from more than 50% to less than 30% area. The bronchus was clean in both two groups compared to the groups that were not treated with Allium sativum CONCLUSION: This study shows that Allium sativum ethanol extract has the ability to prevent lung damage in the smoker rat model. Academy of Medical Sciences of Bosnia and Herzegovina 2023 /pmc/articles/PMC10495143/ /pubmed/37700925 http://dx.doi.org/10.5455/medarh.2023.77.178-182 Text en © 2023 Maya Savira, Dina Keumala Sari, Yetty Machrina, Sry Suryani Widjaja, Adrien Jems Akiles Unitly, Syafruddin Ilyas, Jelita Siregar, Pandiaman Pandia, M. Rusda, Mustafa M Amin https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Paper
Savira, Maya
Sari, Dina Keumala
Machrina, Yetty
Widjaja, Sry Suryani
Unitly, Adrien Jems Akiles
Ilyas, Syafruddin
Siregar, Jelita
Pandia, Pandiaman
Rusda, M.
Amin, Mustafa M
Anti Inflammatory Action of Allium Sativum Ethanol Extract to Prevent Lung Damage in Smoker Rat Model
title Anti Inflammatory Action of Allium Sativum Ethanol Extract to Prevent Lung Damage in Smoker Rat Model
title_full Anti Inflammatory Action of Allium Sativum Ethanol Extract to Prevent Lung Damage in Smoker Rat Model
title_fullStr Anti Inflammatory Action of Allium Sativum Ethanol Extract to Prevent Lung Damage in Smoker Rat Model
title_full_unstemmed Anti Inflammatory Action of Allium Sativum Ethanol Extract to Prevent Lung Damage in Smoker Rat Model
title_short Anti Inflammatory Action of Allium Sativum Ethanol Extract to Prevent Lung Damage in Smoker Rat Model
title_sort anti inflammatory action of allium sativum ethanol extract to prevent lung damage in smoker rat model
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495143/
https://www.ncbi.nlm.nih.gov/pubmed/37700925
http://dx.doi.org/10.5455/medarh.2023.77.178-182
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