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Early and intensive motor training to enhance neurological recovery in people with spinal cord injury: trial protocol

STUDY DESIGN: Protocol for a multi-centre randomised controlled trial (the SCI-MT trial). OBJECTIVES: To determine whether 10 weeks of intensive motor training enhances neurological recovery in people with recent spinal cord injury (SCI). SETTING: Fifteen spinal injury units in Australia, Scotland,...

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Autores principales: Harvey, Lisa A., Glinsky, Joanne V., Chu, Jackie, Herbert, Robert D., Liu, Hueiming, Jan, Stephen, Billot, Laurent, Scivoletto, Giorgio, Spooren, Annemie I., Seelen, Henk A., Ben, Marsha, Tranter, Keira, Chen, Lydia W., Rainey, Donna, Rimmer, Christine, Jorgensen, Vivien, Di Natal, Fernanda, Denis, Sophie, Gollan, Emilie J., Tamburella, Federica, Agostinello, Jacqui, van Laake-Geelen, Charlotte M., Bell, Chris, Lincoln, Claire, Stolwijk, Janneke M., van der Lede, Jessica, Paddison, Sue, Oostra, Kristine, Cameron, Ian D., Weber, Gerard, Sherrington, Catherine, Nunn, Andrew K., Synnott, Emma-Leigh, McCaughey, Euan, Kaur, Jasbeer, Shetty, Sachin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495259/
https://www.ncbi.nlm.nih.gov/pubmed/37414835
http://dx.doi.org/10.1038/s41393-023-00908-z
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author Harvey, Lisa A.
Glinsky, Joanne V.
Chu, Jackie
Herbert, Robert D.
Liu, Hueiming
Jan, Stephen
Billot, Laurent
Scivoletto, Giorgio
Spooren, Annemie I.
Seelen, Henk A.
Ben, Marsha
Tranter, Keira
Chen, Lydia W.
Rainey, Donna
Rimmer, Christine
Jorgensen, Vivien
Di Natal, Fernanda
Denis, Sophie
Gollan, Emilie J.
Tamburella, Federica
Agostinello, Jacqui
van Laake-Geelen, Charlotte M.
Bell, Chris
Lincoln, Claire
Stolwijk, Janneke M.
van der Lede, Jessica
Paddison, Sue
Oostra, Kristine
Cameron, Ian D.
Weber, Gerard
Sherrington, Catherine
Nunn, Andrew K.
Synnott, Emma-Leigh
McCaughey, Euan
Kaur, Jasbeer
Shetty, Sachin
author_facet Harvey, Lisa A.
Glinsky, Joanne V.
Chu, Jackie
Herbert, Robert D.
Liu, Hueiming
Jan, Stephen
Billot, Laurent
Scivoletto, Giorgio
Spooren, Annemie I.
Seelen, Henk A.
Ben, Marsha
Tranter, Keira
Chen, Lydia W.
Rainey, Donna
Rimmer, Christine
Jorgensen, Vivien
Di Natal, Fernanda
Denis, Sophie
Gollan, Emilie J.
Tamburella, Federica
Agostinello, Jacqui
van Laake-Geelen, Charlotte M.
Bell, Chris
Lincoln, Claire
Stolwijk, Janneke M.
van der Lede, Jessica
Paddison, Sue
Oostra, Kristine
Cameron, Ian D.
Weber, Gerard
Sherrington, Catherine
Nunn, Andrew K.
Synnott, Emma-Leigh
McCaughey, Euan
Kaur, Jasbeer
Shetty, Sachin
author_sort Harvey, Lisa A.
collection PubMed
description STUDY DESIGN: Protocol for a multi-centre randomised controlled trial (the SCI-MT trial). OBJECTIVES: To determine whether 10 weeks of intensive motor training enhances neurological recovery in people with recent spinal cord injury (SCI). SETTING: Fifteen spinal injury units in Australia, Scotland, England, Italy, Netherlands, Norway, and Belgium. METHODS: A pragmatic randomised controlled trial will be undertaken. Two hundred and twenty people with recent SCI (onset in the preceding 10 weeks, American Spinal Injuries Association Impairment Scale (AIS) A lesion with motor function more than three levels below the motor level on one or both sides, or an AIS C or D lesion) will be randomised to receive either usual care plus intensive motor training (12 h of motor training per week for 10 weeks) or usual care alone. The primary outcome is neurological recovery at 10 weeks, measured with the Total Motor Score from the International Standards for Neurological Classification of SCI. Secondary outcomes include global measures of motor function, ability to walk, quality of life, participants’ perceptions about ability to perform self-selected goals, length of hospital stay and participants’ impressions of therapeutic benefit at 10 weeks and 6 months. A cost-effectiveness study and process evaluation will be run alongside the trial. The first participant was randomised in June 2021 and the trial is due for completion in 2025. CONCLUSIONS: The findings of the SCI-MT Trial will guide recommendations about the type and dose of inpatient therapy that optimises neurological recovery in people with SCI. TRIAL REGISTRATION: ACTRN12621000091808 (1.2.2021).
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spelling pubmed-104952592023-09-13 Early and intensive motor training to enhance neurological recovery in people with spinal cord injury: trial protocol Harvey, Lisa A. Glinsky, Joanne V. Chu, Jackie Herbert, Robert D. Liu, Hueiming Jan, Stephen Billot, Laurent Scivoletto, Giorgio Spooren, Annemie I. Seelen, Henk A. Ben, Marsha Tranter, Keira Chen, Lydia W. Rainey, Donna Rimmer, Christine Jorgensen, Vivien Di Natal, Fernanda Denis, Sophie Gollan, Emilie J. Tamburella, Federica Agostinello, Jacqui van Laake-Geelen, Charlotte M. Bell, Chris Lincoln, Claire Stolwijk, Janneke M. van der Lede, Jessica Paddison, Sue Oostra, Kristine Cameron, Ian D. Weber, Gerard Sherrington, Catherine Nunn, Andrew K. Synnott, Emma-Leigh McCaughey, Euan Kaur, Jasbeer Shetty, Sachin Spinal Cord Article STUDY DESIGN: Protocol for a multi-centre randomised controlled trial (the SCI-MT trial). OBJECTIVES: To determine whether 10 weeks of intensive motor training enhances neurological recovery in people with recent spinal cord injury (SCI). SETTING: Fifteen spinal injury units in Australia, Scotland, England, Italy, Netherlands, Norway, and Belgium. METHODS: A pragmatic randomised controlled trial will be undertaken. Two hundred and twenty people with recent SCI (onset in the preceding 10 weeks, American Spinal Injuries Association Impairment Scale (AIS) A lesion with motor function more than three levels below the motor level on one or both sides, or an AIS C or D lesion) will be randomised to receive either usual care plus intensive motor training (12 h of motor training per week for 10 weeks) or usual care alone. The primary outcome is neurological recovery at 10 weeks, measured with the Total Motor Score from the International Standards for Neurological Classification of SCI. Secondary outcomes include global measures of motor function, ability to walk, quality of life, participants’ perceptions about ability to perform self-selected goals, length of hospital stay and participants’ impressions of therapeutic benefit at 10 weeks and 6 months. A cost-effectiveness study and process evaluation will be run alongside the trial. The first participant was randomised in June 2021 and the trial is due for completion in 2025. CONCLUSIONS: The findings of the SCI-MT Trial will guide recommendations about the type and dose of inpatient therapy that optimises neurological recovery in people with SCI. TRIAL REGISTRATION: ACTRN12621000091808 (1.2.2021). Nature Publishing Group UK 2023-07-06 2023 /pmc/articles/PMC10495259/ /pubmed/37414835 http://dx.doi.org/10.1038/s41393-023-00908-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Harvey, Lisa A.
Glinsky, Joanne V.
Chu, Jackie
Herbert, Robert D.
Liu, Hueiming
Jan, Stephen
Billot, Laurent
Scivoletto, Giorgio
Spooren, Annemie I.
Seelen, Henk A.
Ben, Marsha
Tranter, Keira
Chen, Lydia W.
Rainey, Donna
Rimmer, Christine
Jorgensen, Vivien
Di Natal, Fernanda
Denis, Sophie
Gollan, Emilie J.
Tamburella, Federica
Agostinello, Jacqui
van Laake-Geelen, Charlotte M.
Bell, Chris
Lincoln, Claire
Stolwijk, Janneke M.
van der Lede, Jessica
Paddison, Sue
Oostra, Kristine
Cameron, Ian D.
Weber, Gerard
Sherrington, Catherine
Nunn, Andrew K.
Synnott, Emma-Leigh
McCaughey, Euan
Kaur, Jasbeer
Shetty, Sachin
Early and intensive motor training to enhance neurological recovery in people with spinal cord injury: trial protocol
title Early and intensive motor training to enhance neurological recovery in people with spinal cord injury: trial protocol
title_full Early and intensive motor training to enhance neurological recovery in people with spinal cord injury: trial protocol
title_fullStr Early and intensive motor training to enhance neurological recovery in people with spinal cord injury: trial protocol
title_full_unstemmed Early and intensive motor training to enhance neurological recovery in people with spinal cord injury: trial protocol
title_short Early and intensive motor training to enhance neurological recovery in people with spinal cord injury: trial protocol
title_sort early and intensive motor training to enhance neurological recovery in people with spinal cord injury: trial protocol
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495259/
https://www.ncbi.nlm.nih.gov/pubmed/37414835
http://dx.doi.org/10.1038/s41393-023-00908-z
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