MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin looping

MacroH2A has established tumour suppressive functions in melanoma and other cancers, but an unappreciated role in the tumour microenvironment. Using an autochthonous, immunocompetent mouse model of melanoma, we demonstrate that mice devoid of macroH2A variants exhibit increased tumour burden compare...

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Detalles Bibliográficos
Autores principales: Filipescu, Dan, Carcamo, Saul, Agarwal, Aman, Tung, Navpreet, Humblin, Étienne, Goldberg, Matthew S., Vyas, Nikki S., Beaumont, Kristin G., Demircioglu, Deniz, Sridhar, Subhasree, Ghiraldini, Flavia G., Capparelli, Claudia, Aplin, Andrew E., Salmon, Hélène, Sebra, Robert, Kamphorst, Alice O., Merad, Miriam, Hasson, Dan, Bernstein, Emily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495263/
https://www.ncbi.nlm.nih.gov/pubmed/37605008
http://dx.doi.org/10.1038/s41556-023-01208-7

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