Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor

Cell growth is regulated by the mammalian/mechanistic target of rapamycin complex 1 (mTORC1), which functions both as a nutrient sensor and a master controller of virtually all biosynthetic pathways. This ensures that cells are metabolically active only when conditions are optimal for growth. Notabl...

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Detalles Bibliográficos
Autores principales: Nicastro, Raffaele, Brohée, Laura, Alba, Josephine, Nüchel, Julian, Figlia, Gianluca, Kipschull, Stefanie, Gollwitzer, Peter, Romero-Pozuelo, Jesus, Fernandes, Stephanie A., Lamprakis, Andreas, Vanni, Stefano, Teleman, Aurelio A., De Virgilio, Claudio, Demetriades, Constantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495264/
https://www.ncbi.nlm.nih.gov/pubmed/37563253
http://dx.doi.org/10.1038/s41556-023-01198-6

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