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Travelling under pressure - hypoxia and shear stress in the metastatic journey
Cancer cell invasion, intravasation and survival in the bloodstream are early steps of the metastatic process, pivotal to enabling the spread of cancer to distant tissues. Circulating tumor cells (CTCs) represent a highly selected subpopulation of cancer cells that tamed these critical steps, and a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495280/ https://www.ncbi.nlm.nih.gov/pubmed/37490147 http://dx.doi.org/10.1007/s10585-023-10224-8 |
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author | Ildiz, Ece Su Gvozdenovic, Ana Kovacs, Werner J Aceto, Nicola |
author_facet | Ildiz, Ece Su Gvozdenovic, Ana Kovacs, Werner J Aceto, Nicola |
author_sort | Ildiz, Ece Su |
collection | PubMed |
description | Cancer cell invasion, intravasation and survival in the bloodstream are early steps of the metastatic process, pivotal to enabling the spread of cancer to distant tissues. Circulating tumor cells (CTCs) represent a highly selected subpopulation of cancer cells that tamed these critical steps, and a better understanding of their biology and driving molecular principles may facilitate the development of novel tools to prevent metastasis. Here, we describe key research advances in this field, aiming at describing early metastasis-related processes such as collective invasion, shedding, and survival of CTCs in the bloodstream, paying particular attention to microenvironmental factors like hypoxia and mechanical stress, considered as important influencers of the metastatic journey. GRAPHICAL ABSTRACT: [Image: see text] |
format | Online Article Text |
id | pubmed-10495280 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-104952802023-09-13 Travelling under pressure - hypoxia and shear stress in the metastatic journey Ildiz, Ece Su Gvozdenovic, Ana Kovacs, Werner J Aceto, Nicola Clin Exp Metastasis Review Cancer cell invasion, intravasation and survival in the bloodstream are early steps of the metastatic process, pivotal to enabling the spread of cancer to distant tissues. Circulating tumor cells (CTCs) represent a highly selected subpopulation of cancer cells that tamed these critical steps, and a better understanding of their biology and driving molecular principles may facilitate the development of novel tools to prevent metastasis. Here, we describe key research advances in this field, aiming at describing early metastasis-related processes such as collective invasion, shedding, and survival of CTCs in the bloodstream, paying particular attention to microenvironmental factors like hypoxia and mechanical stress, considered as important influencers of the metastatic journey. GRAPHICAL ABSTRACT: [Image: see text] Springer Netherlands 2023-07-25 2023 /pmc/articles/PMC10495280/ /pubmed/37490147 http://dx.doi.org/10.1007/s10585-023-10224-8 Text en © The Author(s) 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Ildiz, Ece Su Gvozdenovic, Ana Kovacs, Werner J Aceto, Nicola Travelling under pressure - hypoxia and shear stress in the metastatic journey |
title | Travelling under pressure - hypoxia and shear stress in the metastatic journey |
title_full | Travelling under pressure - hypoxia and shear stress in the metastatic journey |
title_fullStr | Travelling under pressure - hypoxia and shear stress in the metastatic journey |
title_full_unstemmed | Travelling under pressure - hypoxia and shear stress in the metastatic journey |
title_short | Travelling under pressure - hypoxia and shear stress in the metastatic journey |
title_sort | travelling under pressure - hypoxia and shear stress in the metastatic journey |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495280/ https://www.ncbi.nlm.nih.gov/pubmed/37490147 http://dx.doi.org/10.1007/s10585-023-10224-8 |
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