Three new amide derivatives from the fungus Alternaria brassicicola

Three new amide derivatives (alteralkaloids A–C, 1–3) and three known alkaloids (4–6) were afforded after phytochemical investigation of fungus Alternaria brassicicola. The structures of these compounds were confirmed by NMR spectroscopic and HRESIMS data. Furthermore, the absolute configuration of...

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Autores principales: Li, Fengli, Gu, Saisai, Zhang, Sitian, Mo, Shuyuan, Guo, Jieru, Hu, Zhengxi, Zhang, Yonghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495297/
https://www.ncbi.nlm.nih.gov/pubmed/37695377
http://dx.doi.org/10.1007/s13659-023-00391-2
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author Li, Fengli
Gu, Saisai
Zhang, Sitian
Mo, Shuyuan
Guo, Jieru
Hu, Zhengxi
Zhang, Yonghui
author_facet Li, Fengli
Gu, Saisai
Zhang, Sitian
Mo, Shuyuan
Guo, Jieru
Hu, Zhengxi
Zhang, Yonghui
author_sort Li, Fengli
collection PubMed
description Three new amide derivatives (alteralkaloids A–C, 1–3) and three known alkaloids (4–6) were afforded after phytochemical investigation of fungus Alternaria brassicicola. The structures of these compounds were confirmed by NMR spectroscopic and HRESIMS data. Furthermore, the absolute configuration of 1 was determined using the single-crystal X-ray diffraction analysis. Compounds 1–3 belong to a class of amide derivatives that have not been found in nature before, sharing the same characteristic signals of the butyl moiety and amide group. These isolated compounds mentioned above were tested for the cytotoxic activity. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-023-00391-2.
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spelling pubmed-104952972023-09-13 Three new amide derivatives from the fungus Alternaria brassicicola Li, Fengli Gu, Saisai Zhang, Sitian Mo, Shuyuan Guo, Jieru Hu, Zhengxi Zhang, Yonghui Nat Prod Bioprospect Short Communication Three new amide derivatives (alteralkaloids A–C, 1–3) and three known alkaloids (4–6) were afforded after phytochemical investigation of fungus Alternaria brassicicola. The structures of these compounds were confirmed by NMR spectroscopic and HRESIMS data. Furthermore, the absolute configuration of 1 was determined using the single-crystal X-ray diffraction analysis. Compounds 1–3 belong to a class of amide derivatives that have not been found in nature before, sharing the same characteristic signals of the butyl moiety and amide group. These isolated compounds mentioned above were tested for the cytotoxic activity. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-023-00391-2. Springer Nature Singapore 2023-09-11 /pmc/articles/PMC10495297/ /pubmed/37695377 http://dx.doi.org/10.1007/s13659-023-00391-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Short Communication
Li, Fengli
Gu, Saisai
Zhang, Sitian
Mo, Shuyuan
Guo, Jieru
Hu, Zhengxi
Zhang, Yonghui
Three new amide derivatives from the fungus Alternaria brassicicola
title Three new amide derivatives from the fungus Alternaria brassicicola
title_full Three new amide derivatives from the fungus Alternaria brassicicola
title_fullStr Three new amide derivatives from the fungus Alternaria brassicicola
title_full_unstemmed Three new amide derivatives from the fungus Alternaria brassicicola
title_short Three new amide derivatives from the fungus Alternaria brassicicola
title_sort three new amide derivatives from the fungus alternaria brassicicola
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495297/
https://www.ncbi.nlm.nih.gov/pubmed/37695377
http://dx.doi.org/10.1007/s13659-023-00391-2
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